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1/18/2015 4:09:00 PM | Browse: 949 | Download: 942
Publication Name World Journal of Gastroenterology
Manuscript ID 10357
Country/Territory Japan
Received
2014-03-27 21:18
Peer-Review Started
2014-03-28 09:29
To Make the First Decision
2014-05-29 19:14
Return for Revision
2014-06-03 17:42
Revised
2014-06-12 17:22
Second Decision
2014-07-22 16:54
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-07-22 17:15
Articles in Press
2014-07-22 18:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-12-27 20:28
Publish the Manuscript Online
2015-01-18 16:09
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cell Biology
Manuscript Type Autobiography
Article Title Aberrant EphB/ephrin-B expression in experimental gastric lesions and tumor cells
Manuscript Source Unsolicited Manuscript
All Author List Shintaro Uchiyama, Noritaka Saeki and Kazushige Ogawa
Funding Agency and Grant Number
Funding Agency Grant Number
Scientific Research from Japan Society for the Promotion of Science 21580367 (to Ogawa K)
Corresponding Author Kazushige Ogawa, DVM, PhD, Department of Veterinary Anatomy, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-58 Rinku-Ourai-Kita, Izumisano, Osaka 598-8531, Japan. kogawa@vet.osakafu-u.ac.jp
Key Words Gastric ulcer; Gastric dysplasia; Gastric carcinoma cell line; Coexpression; EphB; Ephrin-B
Core Tip A constant/high level of EphB and ephrin-B coexpression was identified as a feature common to experimentally induced gastric dysplasia and human gastric carcinoma cell lines, as compared to normal and regenerating gastric epithelia. Based on these, we proposed that the stable/robust EphB and ephrin-B coexpression is a marker of dysplastic/oncogenic transformation. Eph signaling in tumor cells likely has a suppressive role during tumor progression, with Eph and ephrin coexpressed on the same cell engaging in non-productive interactions via lateral inhibition and thereby silencing downstream signaling. These results can be useful for the early and accurate diagnosis of gastric tumors.
Publish Date 2015-01-18 16:09
Citation Uchiyama S, Saeki N, Ogawa K. Aberrant EphB/ephrin-B expression in experimental gastric lesions and tumor cells. World J Gastroenterol 2015; 21(2): 453-464
URL http://www.wjgnet.com/1007-9327/full/v21/i2/453.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i2.453
Full Article (PDF) WJG-21-453.pdf
Full Article (Word) WJG-21-453.doc
Manuscript File 10357-Review.doc
Answering Reviewers 10357-Answering reviewers.pdf
Copyright License Agreement 10357-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 10357-Language certificate.pdf
Peer-review Report 10357-Peer review(s).pdf
Scientific Misconduct Check 10357-CrossCheck.jpg
Scientific Editor Work List 10357-Scientific editor work list.pdf