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Articles Published Processes
1/18/2015 4:09:00 PM | Browse: 827 | Download: 1046
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Received |
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2014-04-02 09:49 |
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Peer-Review Started |
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2014-04-02 10:13 |
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To Make the First Decision |
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2014-04-28 14:06 |
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Return for Revision |
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2014-05-02 16:03 |
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Revised |
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2014-05-15 19:54 |
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Second Decision |
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2014-07-22 16:54 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2014-07-22 18:17 |
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Articles in Press |
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2014-07-22 18:32 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2014-12-23 21:23 |
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Publish the Manuscript Online |
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2015-01-18 16:09 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Autobiography |
| Article Title |
Increased density of tolerogenic dendritic cells in the small bowel mucosa of celiac patients
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Tamara Vorobjova, Oivi Uibo, Kaire Heilman and Raivo Uibo |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Estonian Research Foundation |
7749 |
| Estonian Research Foundation |
8334 |
| EU Regional Developmental Fund |
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| Estonian Ministry of Education and Research |
SF 0180035s08 |
| Estonian Ministry of Education and Research |
IUT20-43 |
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| Corresponding Author |
Tamara Vorobjova, MD, PhD, Sc med, Senior Researcher, Department of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, Ravila 19, 51014 Tartu, Estonia. tamara.vorobjova@kliinikum.ee |
| Key Words |
CD11c+; CD103+; IDO+; langerin (CD207+) dendritic cells; FOXP3+ regulatory T cells; Small bowel mucosa; Immunohistochemistry; Immunofluorescence; Celiac disease; Type 1 diabetes; Children |
| Core Tip |
Significantly higher densities of CD11c+ dendritic cells (DCs) and of tolerogenic IDO+, CD103+ and Langerin+ DCs in the small bowel mucosa of patients with celiac disease (CD) compared with subjects with normal small bowel mucosa were revealed using immunohistochemistry in 74 patients. This article highlights the participation of diverse DC subsets in the pathological processes in the small bowel mucosa, pointing out the importance of Langerin+ DCs in untreated CD patients with and without type 1 diabetes and indicating the possible involvement of tolerogenic DCs in regulatory T cells development to maintain intestinal immunological tolerance in CD patients. |
| Publish Date |
2015-01-18 16:09 |
| Citation |
Vorobjova T, Uibo O, Heilman K, Uibo R. Increased density of tolerogenic dendritic cells in the small bowel mucosa of celiac patients. World J Gastroenterol 2015; 21(2): 439-452 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i2/439.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i2.439 |
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