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1/18/2015 4:09:00 PM | Browse: 884 | Download: 1145
Publication Name World Journal of Gastroenterology
Manuscript ID 10941
Country/Territory Japan
Received
2014-04-27 13:48
Peer-Review Started
2014-04-27 14:21
To Make the First Decision
2014-05-13 19:53
Return for Revision
2014-05-21 08:25
Revised
Second Decision
2014-07-11 17:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-07-11 17:15
Articles in Press
2014-07-11 17:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-12-26 11:36
Publish the Manuscript Online
2015-01-18 16:09
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Retrospective Study
Article Title Thrombomodulin in the management of acute cholangitis-induced disseminated intravascular coagulation
Manuscript Source Unsolicited Manuscript
All Author List Keigo Suetani, Chiaki Okuse, Kazunari Nakahara, Yosuke Michikawa, Yohei Noguchi, Midori Suzuki, Ryo Morita, Nozomi Sato, Masaki Kato and Fumio Itoh
Funding Agency and Grant Number
Corresponding Author Kazunari Nakahara, PhD, Department of Gastroenterology and Hepatology, St. Marianna University, School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki 216-8511, Japan. nakahara@marianna-u.ac.jp
Key Words Disseminated intravascular coagulation; Acute cholangitis; Thrombomodulin; Biliary drainage; Anticoagulant therapy
Core Tip To evaluate the need for thrombomodulin (rTM) in the management of acute cholangitis (AC)-induced disseminated intravascular coagulation (DIC), we retrospectively compared patients treated with rTM (rTM group) and without rTM (control group). DIC resolution rates were higher in the rTM group (P < 0.01). Multivariate analysis identified only the absence of biliary drainage as significantly associated with persistent DIC (P < 0.01), while there was a trend towards an association between persistent DIC and a lack of rTM (P = 0.08). Therefore, the add-on effects of rTM are anticipated in the treatment of AC-induced DIC, although biliary drainage remains crucial.
Publish Date 2015-01-18 16:09
Citation Suetani K, Okuse C, Nakahara K, Michikawa Y, Noguchi Y, Suzuki M, Morita R, Sato N, Kato M, Itoh F. Thrombomodulin in the management of acute cholangitis-induced disseminated intravascular coagulation. World J Gastroenterol 2015; 21(2): 533-540
URL http://www.wjgnet.com/1007-9327/full/v21/i2/533.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i2.533
Full Article (PDF) WJG-21-533.pdf
Full Article (Word) WJG-21-533.doc
Manuscript File 10941-Review.doc
Answering Reviewers 10941-Answering reviewers.pdf
Copyright License Agreement 10941-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 10941-Language certificate.pdf
Peer-review Report 10941-Peer review.pdf
Scientific Misconduct Check 10941-CrossCheck.jpg
Scientific Editor Work List 10941-Scientific editor work list.pdf