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10/29/2014 7:34:00 PM | Browse: 1041 | Download: 1219
Publication Name World Journal of Gastroenterology
Manuscript ID 11028
Country/Territory China
Received
2014-05-01 09:03
Peer-Review Started
2014-05-02 11:33
To Make the First Decision
2014-05-29 19:01
Return for Revision
2014-06-04 16:25
Revised
2014-06-25 08:33
Second Decision
2014-07-16 12:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-07-16 13:12
Articles in Press
2014-07-16 17:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-07-22 21:35
Typeset the Manuscript
2014-10-15 11:32
Publish the Manuscript Online
2014-10-29 19:34
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Autobiography
Article Title Effect of Danshao Huaxian capsule on Gremlin and bone morphogenetic protein-7 expression in hepatic fibrosis in rats
Manuscript Source Unsolicited Manuscript
All Author List Xue-Ke Zhao, Ming-Liang Cheng, Rong-Min Wu, Yu-Mei Yao, Mao Mu, Juan-Juan Zhu, Bao-Fang Zhang and Ming-Yu Zhou
Funding Agency and Grant Number
Funding Agency Grant Number
Science and Technology Project of Guizhou Province, China SZ [2008] 3049
Corresponding Author Ming-Liang Cheng, MD, Department of Infectious Diseases, Affiliated Hospital of Guiyang Medical College, No. 28, Guiyi Road, Guiyang 550004, Guizhou Province, China. chengml@21cn.com
Key Words Hepatic fibrosis; Bone morphogenetic protein; Gremlin; Transforming growth factor; Traditional Chinese herbs
Core Tip Hepatic fibrosis, as a refractory disease, represents a current threat to global health. To date, no ideal drug therapies have been identified, and drugs for liver fibrosis remain in the exploratory stage of development. Previous experimental and clinical studies showed that Danshao Huaxian capsule (DHC, originally called Handan Ganle) demonstrated efficacy in treating liver fibrosis. In this study, the effect of DHC on the expression of Gremlin and bone morphogenetic protein 7 (BMP-7) in a liver fibrosis rat model was observed to explore its potential mechanism for treating liver fibrosis. We found that the therapeutic mechanism of DHC for hepatic fibrosis in rats may be associated with inhibition of the expression of Gremlin and up-regulation of the expression of BMP-7.
Publish Date 2014-10-29 19:34
Citation Zhao XK, Cheng ML, Wu RM, Yao YM, Mu M, Zhu JJ, Zhang BF, Zhou MY. Effect of Danshao Huaxian capsule on Gremlin and bone morphogenetic protein-7 expression in hepatic fibrosis in rats. World J Gastroenterol 2014; 20(40): 14875-14883
URL http://www.wjgnet.com/1007-9327/full/v20/i40/14875.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i40.14875
Full Article (PDF) WJG-20-14875.pdf
Full Article (Word) WJG-20-14875.doc
Manuscript File 11028-Review.doc
Answering Reviewers 11028-Answering reviewers.pdf
Copyright License Agreement 11028-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 11028-Language certificate.pdf
Peer-review Report 11028-Peer reviews.pdf
Scientific Misconduct Check 11028-CrossCheck.jpg
Scientific Editor Work List 11028-Scientific editor work list.pdf