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1/6/2015 9:08:00 AM | Browse: 587 | Download: 848
Publication Name World Journal of Gastroenterology
Manuscript ID 11114
Country/Territory China
2014-05-05 19:11
Peer-Review Started
2014-05-06 00:00
To Make the First Decision
2014-05-29 19:12
Return for Revision
2014-06-04 11:17
2014-06-21 23:24
Second Decision
2014-09-05 16:40
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-09-05 17:07
Articles in Press
2014-09-05 17:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-09-19 09:53
Typeset the Manuscript
2014-12-16 21:45
Publish the Manuscript Online
2015-01-06 09:08
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Review
Article Title Role of interleukin-22 in inflammatory bowel disease
Manuscript Source Unsolicited Manuscript
All Author List Lin-Jing Li, Chen Gong, Mei-Hua Zhao and Bai-Sui Feng
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81070288
National Natural Science Foundation of China 81270452
Medical Science and Technology Foundation of Henan Province 201001004
Science and Technology Leader Overseas Training Foundation of Henan Province 201201013
Corresponding author Bai-Sui Feng, MD, PhD, Professor, Department of Gastroenterology, the Fifth Affiliated Hospital of Zhengzhou University, 3 Kangfu Front Street, Erqi District, Zhengzhou 450000, Henan Province, China. fbs163@163.com
Keywords Inflammatory bowel disease; Interleukin-22; Signal transducer and activator of transcription 3
Core Tip Interleukin (IL)-22 is expressed by adaptive immune system cells and innate lymphocytes. Several cytokines and many transcriptional factors and T regulatory cells can regulate IL-22 expression. Through activation of signal transducer and activator of transcription 3 signaling cascades, IL-22 induces antimicrobial, proliferative and antiapoptotic pathways, which can help fix damaged tissue and promote tissue repair mechanisms. IL-22 is also associated with inflammatory bowel disease (IBD) susceptibility genes that regulate inflammatory responses in tissues. All of these processes play crucial roles in IBD pathogenesis and collectively provide an important rationale for the development of novel therapeutic measures for this disease.
Publish Date 2015-01-06 09:08
Citation Li LJ, Gong C, Zhao MH, Feng BS. Role of interleukin-22 in inflammatory bowel disease. World J Gastroenterol 2014; 20(48): 18177-18188
Url http://www.wjgnet.com/1007-9327/full/v20/i48/18177.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i48.18177
Full Article (PDF) WJG-20-18177.pdf
Full Article (Word) WJG-20-18177.doc
Manuscript File 11114-Review.doc
Answering Reviewers 11114-Answering reviewers.pdf
Copyright License Agreement 11114-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 11114-Language certificate.PDF
Peer-review Report 11114-Peer review(s).pdf
Scientific Misconduct Check 11114-CrossCheck.jpg
Scientific Editor Work List 11114-Scientific editor work list.pdf