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1/18/2015 4:09:00 PM | Browse: 501 | Download: 442
Publication Name World Journal of Gastroenterology
Manuscript ID 11186
Country/Territory Japan
Received
2014-05-08 09:32
Peer-Review Started
2014-05-08 13:17
To Make the First Decision
2014-05-29 19:12
Return for Revision
2014-06-04 11:20
Revised
2014-06-17 15:41
Second Decision
2014-07-22 16:57
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-07-22 18:18
Articles in Press
2014-07-22 18:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-12-30 19:15
Publish the Manuscript Online
2015-01-18 16:09
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Retrospective Study
Article Title Mutations of pre-core and basal core promoter before and after hepatitis B e antigen seroconversion
Manuscript Source Unsolicited Manuscript
All Author List Nozomi Kamijo, Akihiro Matsumoto, Takeji Umemura, Soichiro Shibata, Yuki Ichikawa, Takefumi Kimura, Michiharu Komatsu and Eiji Tanaka
Funding Agency and Grant Number
Funding Agency Grant Number
Research grant from the Ministry of Health, Labor, and Welfare of Japan
Corresponding author Takeji Umemura, MD, PhD, Associate Professor, Department of Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan. tumemura@shinshu-u.ac.jp
Keywords Seroconversion; Hepatitis B core-related antigen; pre-core; Basal core promoter; Mutation; Hepatitis B surface antigen; Hepatitis B virus DNA
Core Tip The exact roles of pre-core (pre-C) and basal core promoter (BCP) mutations remain unclear before and after hepatitis B e antigen (HBeAg) seroconversion. Here, although the pre-C mutant became predominant in the HBeAg seroconversion group during follow-up, the proportion of the BCP mutation did not change. Hepatitis B virus (HBV) viral markers were significantly higher in patients without the mutations in an HBeAg positive status. HBV DNA and hepatitis B surface antigen levels were higher in patients with the pre-C mutation in an anti-HBe positive status. Taken together, the association of the pre-C mutation on viral load appears to be opposite before and after HBeAg seroconversion in patients with HBV infection.
Publish Date 2015-01-18 16:09
Citation Kamijo N, Matsumoto A, Umemura T, Shibata S, Ichikawa Y, Kimura T, Komatsu M, Tanaka E. Mutations of pre-core and basal core promoter before and after hepatitis B e antigen seroconversion. World J Gastroenterol 2015; 21(2): 541-548
Url http://www.wjgnet.com/1007-9327/full/v21/i2/541.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i2.541
Full Article (PDF) WJG-21-541.pdf
Full Article (Word) WJG-21-541.doc
Manuscript File 11186-Review.docx
Answering Reviewers 11186-Answering reviewers.pdf
Copyright License Agreement 11186-Copyright assignment.pdf
Peer-review Report 11186-Peer review(s).pdf
Scientific Misconduct Check 11186-CrossCheck.jpg
Scientific Editor Work List 11186-Scientific editor work list.pdf