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Articles Published Processes
12/5/2014 11:43:00 AM | Browse: 1119 | Download: 1323
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Received |
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2014-05-22 08:52 |
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Peer-Review Started |
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2014-05-22 13:36 |
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To Make the First Decision |
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2014-06-10 13:23 |
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Return for Revision |
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2014-06-18 13:52 |
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Revised |
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2014-07-11 02:36 |
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Second Decision |
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2014-07-25 09:18 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2014-07-25 09:38 |
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Articles in Press |
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2014-07-25 09:59 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2014-08-26 07:08 |
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Typeset the Manuscript |
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2014-11-11 13:30 |
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Publish the Manuscript Online |
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2014-11-20 20:51 |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Minireviews |
Article Title |
Ribavirin induced hemolysis: A novel mechanism of action against chronic hepatitis C virus infection
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Kaartik Soota and Benedict Maliakkal |
Funding Agency and Grant Number |
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Corresponding Author |
Benedict Maliakkal, MD, Department of Gastroenterology and Hepatology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, United States. benedict_maliakkal@urmc.rochester.edu |
Key Words |
Chronic hepatitis C; Therapy; Ribavirin; Hemolysis; Heme oxygenase-1 |
Core Tip |
Innate immune tolerance leads to chronic hepatitis C virus (cHCV) infection as a pro-inflammatory state develops within the liver. The suppression of heme oxygenase-1 (HMOX1) by HCV plays a major role in perpetuating the infection and inflammation. Ribavirin (RBV) therapy, which increases heme delivery to the liver, can overcome this inhibition. HMOX1 induction in Kupffer cells reduces the pro-inflammatory state produced by HCV, whereas HMOX1 induction in hepatocytes decreases viral multiplication and apoptosis. HMOX1-induced hemolysis in the liver results in higher sustained viral response rates when RBV is used with interferon in the treatment of cHCV. |
Publish Date |
2014-11-20 20:51 |
Citation |
Soota K, Maliakkal B. Ribavirin induced hemolysis: A novel mechanism of action against chronic hepatitis C virus infection. World J Gastroenterol 2014; 20(43): 16184-16190 |
URL |
http://www.wjgnet.com/1007-9327/full/v20/i43/16184.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v20.i43.16184 |
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