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12/5/2014 11:43:00 AM | Browse: 588 | Download: 649
Publication Name World Journal of Gastroenterology
Manuscript ID 11456
Country/Territory United States
2014-05-22 08:52
Peer-Review Started
2014-05-22 13:36
To Make the First Decision
2014-06-10 13:23
Return for Revision
2014-06-18 13:52
2014-07-11 02:36
Second Decision
2014-07-25 09:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-07-25 09:38
Articles in Press
2014-07-25 09:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-08-26 07:08
Typeset the Manuscript
2014-11-11 13:30
Publish the Manuscript Online
2014-11-20 20:51
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Minireviews
Article Title Ribavirin induced hemolysis: A novel mechanism of action against chronic hepatitis C virus infection
Manuscript Source Unsolicited Manuscript
All Author List Kaartik Soota and Benedict Maliakkal
Funding Agency and Grant Number
Corresponding author Benedict Maliakkal, MD, Department of Gastroenterology and Hepatology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, United States. benedict_maliakkal@urmc.rochester.edu
Key Words Chronic hepatitis C; Therapy; Ribavirin; Hemolysis; Heme oxygenase-1
Core Tip Innate immune tolerance leads to chronic hepatitis C virus (cHCV) infection as a pro-inflammatory state develops within the liver. The suppression of heme oxygenase-1 (HMOX1) by HCV plays a major role in perpetuating the infection and inflammation. Ribavirin (RBV) therapy, which increases heme delivery to the liver, can overcome this inhibition. HMOX1 induction in Kupffer cells reduces the pro-inflammatory state produced by HCV, whereas HMOX1 induction in hepatocytes decreases viral multiplication and apoptosis. HMOX1-induced hemolysis in the liver results in higher sustained viral response rates when RBV is used with interferon in the treatment of cHCV.
Publish Date 2014-11-20 20:51
Citation Soota K, Maliakkal B. Ribavirin induced hemolysis: A novel mechanism of action against chronic hepatitis C virus infection. World J Gastroenterol 2014; 20(43): 16184-16190
Url http://www.wjgnet.com/1007-9327/full/v20/i43/16184.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i43.16184
Full Article (PDF) WJG-20-16184.pdf
Full Article (Word) WJG-20-16184.doc
Manuscript File 11456-Review.docx
Answering Reviewers 11456-Answering reviewers.pdf
Copyright License Agreement 11456-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 11456-Language certificate.pdf
Peer-review Report 11456-Peer reviews.pdf
Scientific Misconduct Check 11456-CrossCheck.jpg
Scientific Editor Work List 11456-Scientific editor work list.pdf