Publication Name	World Journal of Hematology
Manuscript ID	1146
Country	Greece

Received	2012-11-15 11:29
Peer-Review Started	2012-11-15 18:25
To Make the First Decision	2013-03-11 14:51
Return for Revision	2013-03-18 09:13
Revised
Second Decision	2013-04-10 16:44
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-04-11 04:36
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-05-12 23:02
Publish the Manuscript Online	2013-06-20 15:35

ISSN	2218-6204 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Hematology
Manuscript Type	Editorial
Article Title	Contribution of new immunoglobulin-derived biomarkers in plasma cell dyscrasias and lymphoproliferative disorders
Manuscript Source	Invited Manuscript
All Author List	Marie-Christine Kyrtsonis, Dimitrios Maltezas, Efstathios Koulieris, Tatiana Tzenou and Stephen J Harding
Funding Agency and Grant Number
Corresponding Author	Marie-Christine Kyrtsonis, MD, PhD, Assistant Professor of Hematology, Haematology Section of 1st Department of Propaedeutic Internal Medicine, Athens Medical School, Laikon University Hospital, Agiou Thoma 17, 11527 Athens, Greece. mck@ath.forthnet.gr
Key Words	Immunoglobulin quantification; Freelite™; Hevylite™; Diagnosis; Monitoring; Prognosis
Core Tip	Recently manufactured assays allow the quantification of serum immunoglobulin (Ig) free light chain (sFLC) or of κ or λ restricted heavy Ig chain separately (HLC). These measurements, or the calculation of their corresponding ratios, were shown useful for routine clinical practice in Hematology. sFLC measurements added important prognostic information for monoclonal gammopathy of undetermined significance (MGUS), multiple myeloma (MM), amyloid light-chain (AL) amyloidosis, Waldenstrom’s macroglobulinemia and chronic lymphocytic leukemia while they contributed to accurate follow-up of MGUS, MM and AL amyloidosis patients. HLC measurements are more recent and mainly concern MM in which they constituted a prognostic marker.
Publish Date	2013-06-20 15:35
Citation	Kyrtsonis MC, Maltezas D, Koulieris E, Tzenou T, Harding SJ. Contribution of new immunoglobulin-derived biomarkers in plasma cell dyscrasias and lymphoproliferative disorders. World J Hematol 2013; 2(2): 6-12
URL	http://www.wjgnet.com/2218-6204/full/v2/i2/6.htm
DOI	http://dx.doi.org/10.5315/wjh.v2.i2.6

Full Article (PDF)	WJH-2-6.pdf
Manuscript File	1146-Review.doc
Answering Reviewers	1146-Answering reviewers.pdf
Copyright License Agreement	1146-Copyright assignment.pdf
Peer-review Report	1146-Peer review.pdf
Scientific Editor Work List	1146-Scientific editor work list.doc