Publication Name	World Journal of Gastroenterology
Manuscript ID	11541
Country	China

Received	2014-05-27 09:02
Peer-Review Started	2014-05-27 21:22
To Make the First Decision	2014-06-27 17:43
Return for Revision	2014-07-03 10:14
Revised	2014-07-11 13:43
Second Decision	2014-09-05 16:40
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-09-05 17:11
Articles in Press	2014-09-05 17:25
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-09-24 23:46
Typeset the Manuscript	2015-01-16 17:37
Publish the Manuscript Online	2015-01-27 15:33

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Novel insights into the mechanisms whereby isoflavones protect against fatty liver disease
Manuscript Source	Unsolicited Manuscript
All Author List	Long-Xin Qiu and Tong Chen
Funding Agency and Grant Number	Funding Agency Grant Number Science and Technology Planning Project of Longyan City 2012LY44 Fujian Province, China 2010N0023
Corresponding Author	Long-Xin Qiu, PhD, School of Life Sciences, Longyan University, 1 North Dongxiao Road, Longyan 364000, Fujian Province, China. qlongxin@tom.com
Key Words	Isoflavones; Fatty liver disease; Aldose reductase; Fructose; Peroxisome proliferator-activated receptor α; Cytochrome P450 2E1; Endotoxin
Core Tip	The aldose reductase (AR)/polyol pathway has recently been reported to be involved in the development of fatty liver disease (FLD) via various pathways. Some isoflavones have been reported to be potent AR inhibitors. Here, we review the anti-FLD actions of isoflavones and the proposed mechanism whereby isoflavones protect against FLD, with regard to the AR/polyol pathway. We propose that isoflavones block the AR/polyol pathway to suppress fructose production in the liver, improve peroxisome-proliferator-activated-receptor-α-mediated fatty acid oxidation, ameliorate cytochrome-P450-2E1-mediated oxidative stress, and attenuate AR/gut bacterial endotoxin-mediated cytokine overproduction, which in turn alleviates the progression of FLD.
Publish Date	2015-01-27 15:33
Citation	Qiu LX, Chen T. Novel insights into the mechanisms where¬by isoflavones protect against fatty liver disease. World J Gastroenterol 2015; 21(4): 1099-1107
URL	http://www.wjgnet.com/1007-9327/full/v21/i4/1099.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i4.1099

Full Article (PDF)	WJG-21-1099.pdf
Full Article (Word)	WJG-21-1099.doc
Manuscript File	11541-Review.doc
Answering Reviewers	11541-Answering reviewers.pdf
Copyright License Agreement	11541-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	11541-Language certificate.PDF
Peer-review Report	11541-Peer review(s).pdf
Scientific Misconduct Check	11541-CrossCheck.jpg
Scientific Editor Work List	11541-Scientific editor work list.pdf