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1/27/2015 3:33:00 PM | Browse: 846 | Download: 445
Publication Name World Journal of Gastroenterology
Manuscript ID 11541
Country of Manuscript Source China
Received
2014-05-27 09:02
Peer-Review Started
2014-05-27 21:22
To Make the First Decision
2014-06-27 17:43
Return for Revision
2014-07-03 10:14
Revised
2014-07-11 13:43
Second Decision
2014-09-05 16:40
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-09-05 17:11
Articles in Press
2014-09-05 17:25
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-09-24 23:46
Typeset the Manuscript
2015-01-16 17:37
Publish the Manuscript Online
2015-01-27 15:33
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript type Minireviews
Article Title Novel insights into the mechanisms whereby isoflavones protect against fatty liver disease
Manuscript Source Unsolicited Manuscript
All Author List Long-Xin Qiu and Tong Chen
Funding Agency and Grant Number
Funding Agency Grant Number
Science and Technology Planning Project of Longyan City 2012LY44
Fujian Province, China 2010N0023
Correspondence To Long-Xin Qiu, PhD, School of Life Sciences, Longyan University, 1 North Dongxiao Road, Longyan 364000, Fujian Province, China. qlongxin@tom.com
Keywords Isoflavones; Fatty liver disease; Aldose reductase; Fructose; Peroxisome proliferator-activated receptor α; Cytochrome P450 2E1; Endotoxin
Core Tip The aldose reductase (AR)/polyol pathway has recently been reported to be involved in the development of fatty liver disease (FLD) via various pathways. Some isoflavones have been reported to be potent AR inhibitors. Here, we review the anti-FLD actions of isoflavones and the proposed mechanism whereby isoflavones protect against FLD, with regard to the AR/polyol pathway. We propose that isoflavones block the AR/polyol pathway to suppress fructose production in the liver, improve peroxisome-proliferator-activated-receptor-α-mediated fatty acid oxidation, ameliorate cytochrome-P450-2E1-mediated oxidative stress, and attenuate AR/gut bacterial endotoxin-mediated cytokine overproduction, which in turn alleviates the progression of FLD.
Publish Date 2015-01-27 15:33
Citation Qiu LX, Chen T. Novel insights into the mechanisms where¬by isoflavones protect against fatty liver disease. World J Gastroenterol 2015; 21(4): 1099-1107
Url http://www.wjgnet.com/1007-9327/full/v21/i4/1099.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i4.1099
Full Article (PDF) WJG-21-1099.pdf
Full Article (Word) WJG-21-1099.doc
Manuscript File 11541-Review.doc
Answering Reviewers 11541-Answering reviewers.pdf
Copyright License Agreement 11541-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 11541-Language certificate.PDF
Peer-review Report 11541-Peer review(s).pdf
Scientific Misconduct Check 11541-CrossCheck.jpg
Scientific Editor Work List 11541-Scientific editor work list.pdf