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Publication Name World Journal of Nephrology
Manuscript ID 11542
Country/Territory Brazil
Received
2014-05-27 09:00
Peer-Review Started
2014-05-27 11:56
To Make the First Decision
2014-06-27 11:53
Return for Revision
2014-06-27 17:56
Revised
2014-07-07 22:47
Second Decision
2014-07-29 09:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-07-29 10:09
Articles in Press
2014-07-29 10:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-09-30 16:24
Publish the Manuscript Online
2014-10-19 20:47
ISSN 2220-6124 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Urology & Nephrology
Manuscript Type Review
Article Title Renin-angiotensin system in the kidney: What is new?
Manuscript Source Invited Manuscript
All Author List Fernanda M Ferrão, Lucienne S Lara and Jennifer Lowe
Funding Agency and Grant Number
Funding Agency Grant Number
Carlos Chagas Filho Rio de Janeiro State Research Foundation (FAPERJ)
National Institute of Science and Technology for Structural Biology and Bioimaging, Brazilian National Research Council (CNPq)
Corresponding Author Jennifer Lowe, MSc, PhD, Laboratório de Físico-Química Biológica, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, UFRJ-CCS-Bloco G-Sala G1-037, Rio de Janeiro 21941-902, Brazil. lowe@biof.ufrj.br
Key Words Renin-angiotensin system; Angiotensin Ⅱ; Kidney; Hypertension treatment; Receptor
Core Tip Activation of the angiotensin converting enzyme (ACE)/ Angiotensin Ⅱ (Ang Ⅱ)/AT1 axis leads to vasoconstriction, anti-diuresis, anti-natriuresis, release of aldosterone and anti-diuretic hormone, which can result in hypertension, renal and cardiovascular diseases. Inhibition of renin and ACE or blocking AT1 receptor is the most used therapies for heart failure and hypertension. Nevertheless, the discovery of local Ang Ⅱ synthesis, new Ang Ⅱ metabolites, receptors and axis of this system, makes possible the development of new drugs and strategies for renal and cardiovascular diseases treatment, such as activation of ACE2/Ang-(1-7)/Mas axis, which presents opposite effects of AT1 activation by Ang Ⅱ.
Publish Date 2014-10-19 20:47
Citation Ferrão FM, Lara LS, Lowe J. Renin-angiotensin system in the kidney: What is new? World J Nephrol 2014; 3(3): 64-76
URL http://www.wjgnet.com/2220-6124/full/v3/i3/64.htm
DOI http://dx.doi.org/10.5527/wjn.v3.i3.64
Full Article (PDF) WJN-3-64.pdf
Full Article (Word) WJN-3-64.doc
Manuscript File 11542-Review.doc
Answering Reviewers 11542-Answering reviewers.pdf
Copyright License Agreement 11542-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 11542-Language certificate.pdf
Peer-review Report 11542-Peer review(s).pdf
Scientific Misconduct Check 11542-CrossCheck.jpg
Scientific Editor Work List 11542-Scientific editor work list.pdf