Publication Name	World Journal of Experimental Medicine
Manuscript ID	11547
Country	United States

Received	2014-05-27 08:33
Peer-Review Started	2014-05-27 12:03
To Make the First Decision	2014-07-10 17:24
Return for Revision	2014-07-11 14:57
Revised	2014-07-15 06:18
Second Decision	2014-08-31 16:55
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-08-31 17:09
Articles in Press	2014-08-31 17:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-06 08:25
Publish the Manuscript Online	2014-11-19 14:49

ISSN	2220-315x (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Geriatrics & Gerontology
Manuscript Type	Review
Article Title	Aging: A mitochondrial DNA perspective, critical analysis and an update
Manuscript Source	Invited Manuscript
All Author List	Inna N Shokolenko, Glenn L Wilson and Mikhail F Alexeyev
Funding Agency and Grant Number	Funding Agency Grant Number National Institutes of Health grant ES03456 National Institutes of Health grant PO1 HL66299 National Institutes of Health grant OD010944
Corresponding Author	Mikhail Alexeyev, PhD, Department of Cell Biology and Neuroscience, University of South Alabama, 5851 USA Dr. North, MSB1201, Mobile, AL 36688, United States. malexeye@southalabama.edu
Key Words	Mitochondrial DNA; Reactive oxygen species; DNA damage; DNA repair; Somatic mtDNA mutations; Antioxidants; Reactive oxygen species signaling; Mitochondrial DNA degradation; Electron transport; Aging
Core Tip	The notion of reactive oxygen species (ROS) -mediated accumulation of mutations in mitochondrial DNA (mtDNA) as a driving force behind aging is increasingly losing ground forcing a revision of the Mitochondrial Theory of Aging. While mitochondrial involvement remains in the center of attention of aging research, the focus is shifting from mtDNA mutations to mitochondrial physiology. The positive effect of increased ROS production on longevity is increasingly viewed as evidence that increased ROS production in aging may be adaptive rather than maladaptive. This novel paradigm explains failure of antioxidants to delay aging in clinical trials.
Publish Date	2014-11-19 14:49
Citation	Shokolenko IN, Wilson GL, Alexeyev MF. Aging: A mitochondrial DNA perspective, critical analysis and an update. World J Exp Med 2014; 4(4): 46-57
URL	http://www.wjgnet.com/2220-315X/full/v4/i4/46.htm
DOI	http://dx.doi.org/10.5493/wjem.v4.i4.46

Full Article (PDF)	WJEM-4-46.pdf
Full Article (Word)	WJEM-4-46.doc
Manuscript File	11547-Review.docx
Answering Reviewers	11547-Answering reviewers.pdf
Copyright License Agreement	11547-Copyright assignment.pdf
Peer-review Report	11547-Peer review(s).pdf
Scientific Misconduct Check	11547-CrossCheck.jpg
Scientific Editor Work List	11547-Scientific editor work list.pdf