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12/18/2014 5:08:00 PM | Browse: 1214 | Download: 1328
Publication Name World Journal of Gastroenterology
Manuscript ID 11901
Country/Territory Japan
Received
2014-06-11 13:43
Peer-Review Started
2014-06-11 15:38
To Make the First Decision
2014-07-09 12:01
Return for Revision
2014-07-15 10:58
Revised
2014-07-18 21:50
Second Decision
2014-09-16 13:39
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-09-16 13:51
Articles in Press
2014-09-16 13:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-12-03 17:42
Publish the Manuscript Online
2014-12-18 17:08
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Topic Highlights
Article Title Alternative splicing of DNA damage response genes and gastrointestinal cancers
Manuscript Source Invited Manuscript
All Author List Bahityar Rahmutulla, Kazuyuki Matsushita and Fumio Nomura
Funding Agency and Grant Number
Corresponding Author Kazuyuki Matsushita, MD, PhD, Associate Professor, Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. kmatsu@faculty.chiba-u.jp
Key Words Alternative splicing; DNA damage; Gastrointestinal cancer; Mutation; Genetic instability
Core Tip Alternative splicing is a fundamental process of gene regulation in eukaryotes. Alternative splicing of DNA damage repair proteins is a significant cause of gene mutations, and those mutations in turn affect alternative splicing in cancer. Alternative splicing is associated with tumorigenesis by contributing to genetic instability. Therefore, alternative splicing of DNA damage response-related genes has an important role in tumorigenesis, survival, and growth of gastrointestinal cancers. In summary, the alternative splicing variants of these genes could be potential targets for both diagnosis and treatment of gastrointestinal cancers.
Publish Date 2014-12-18 17:08
Citation Rahmutulla B, Matsushita K, Nomura F. Alternative splicing of DNA damage response genes and gastrointestinal cancers. World J Gastroenterol 2014; 20(46): 17305-17313
URL http://www.wjgnet.com/1007-9327/full/v20/i46/17305.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i46.17305
Full Article (PDF) WJG-20-17305.pdf
Full Article (Word) WJG-20-17305.doc
Manuscript File 11901-Review.docx
Answering Reviewers 11901-Answering reviewers.pdf
Copyright License Agreement 11901-Copyright assignment.pdf
Peer-review Report 11901-Peer reviews.pdf
Scientific Misconduct Check 11901-CrossCheck.jpg
Scientific Editor Work List 11901-Scientific editor work list.pdf