| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Clinical Trials Study |
| Article Title |
Effects of oral tacrolimus as a rapid induction therapy in ulcerative colitis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ken Kawakami, Takuya Inoue, Mitsuyuki Murano, Ken Narabayashi, Sadaharu Nouda, Kumi Ishida, Yosuke Abe, Koji Nogami, Nobuyuki Hida, Hirokazu Yamagami, Kenji Watanabe, Eiji Umegaki, Shiro Nakamura, Tetsuo Arakawa and Kazuhide Higuchi |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Ken Kawakami, MD, Second Department of Internal Medicine, Osaka Medical College, 2-7 Daigakumachi, Takatsuki city, Osaka 569-8686, Japan. in2090@poh.osaka-med.ac.jp |
| Key Words |
Ulcerative colitis; Tacrolimus; Rapid induction therapy; Steroid-refractory ulcerative colitis; Inflammatory bowel disease |
| Core Tip |
A prospective, multicenter, observation study was conducted to determine the efficacy and safety of rapid induction therapy with oral tacrolimus without meal in patients with steroid-refractory ulcerative colitis. Rapid induction therapy could achieve the appropriate trough level (10-15 ng/mL) within the first 7 d and revealed a high remission rate 28 d after the initiation of the treatment. Treatment was well tolerated. Rapid induction therapy with oral tacrolimus appears to be a useful therapy for the treatment of refractory ulcerative colitis. |
| Publish Date |
2015-02-11 17:56 |
| Citation |
Kawakami K, Inoue T, Murano M, Narabayashi K, Nouda S, Ishida K, Abe Y, Nogami K, Hida N, Yamagami H, Watanabe K, Umegaki E, Nakamura S, Arakawa T, Higuchi K. Effects of oral tacrolimus as a rapid induction therapy in ulcerative colitis. World J Gastroenterol 2015; 21(6): 1880-1886 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i6/1880.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i6.1880 |
