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2/11/2015 4:38:00 PM | Browse: 970 | Download: 1053
Publication Name World Journal of Gastroenterology
Manuscript ID 12036
Country/Territory China
Received
2014-06-19 09:19
Peer-Review Started
2014-06-19 19:12
To Make the First Decision
2014-07-21 14:04
Return for Revision
2014-07-28 16:27
Revised
2014-09-03 14:58
Second Decision
2014-11-17 12:03
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-11-19 09:08
Articles in Press
2014-11-19 09:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-12-02 21:56
Typeset the Manuscript
2015-01-31 16:29
Publish the Manuscript Online
2015-02-11 16:38
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Biochemistry & Molecular Biology
Manuscript Type Basic Study
Article Title Mechanism of action of gypenosides on type 2 diabetes and non-alcoholic fatty liver disease in rats
Manuscript Source Unsolicited Manuscript
All Author List Qin He, Jin-Ke Li, Fang Li, Ru-Gui Li, Guo-Qing Zhan, Gang Li, Wei-Xing Du and Hua-Bing Tan
Funding Agency and Grant Number
Funding Agency Grant Number
Bureau of Public Health of Hubei Province
Corresponding Author Hua-Bing Tan, Professor, Department of Infectious Diseases and Lab of Liver Disease, Renmin Hospital, Hubei University of Medicine, 39 Chaoyangzhong Road, Shiyan 442000, Hubei Province, China. tanhb_2013@163.com
Key Words Gypenosides; Type 2 diabetes mellitus; Non-alcoholic fatty liver; PPARγ; Cytochrome P4501A1
Core Tip Gypenosides (GPs) are one of the most phar-macologically active components in G. pentaphyllum. Intervention with GPs significantly decreased the levels of aspartate aminotransferase, alanine aminotransferase, blood glucose, insulin, triglycerides and total cholesterol in type 2 diabetes mellitus and non-alcoholic fatty liver disease (T2DM-NAFLD) model rats, down-regulated the expression of TNF-α, NF-κB, rabbit anti-proliferator activated receptory (PPARγ) and rabbit anti-cytochrome P4501A1 (CYP1A1) mRNA, decreased the infiltration of liver fats and reversed the histopathological changes in a dose-dependent manner. These findings suggest that GPs have a protective effect against T2DM-NAFLD by down-regulating the expression of TNF-α and NF-κB proteins, and PPARγ and CYP4501A1 mRNAs.
Publish Date 2015-02-11 16:38
Citation He Q, Li JK, Li F, Li RG, Zhan GQ, Li G, Du WX, Tan HB. Mechanism of action of gypenosides on type 2 diabetes and non-alcoholic fatty liver disease in rats. World J Gastroenterol 2015; 21(7): 2058-2066
URL http://www.wjgnet.com/1007-9327/full/v21/i7/2058.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i7.2058
Full Article (PDF) WJG-21-2058.pdf
Full Article (Word) WJG-21-2058.doc
Manuscript File 12036-Review.doc
Answering Reviewers 12036-Answering reviewers.pdf
Copyright License Agreement 12036-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 12036-Language certificate.pdf
Peer-review Report 12036-Peer review.pdf
Scientific Misconduct Check 12036-CorssCheck.jpg
Scientific Editor Work List 12036-Scientific editor work list.pdf