Publication Name	World Journal of Gastroenterology
Manuscript ID	1215
Country	Brazil

Received	2012-11-21 20:50
Peer-Review Started	2012-11-22 16:03
To Make the First Decision	2012-12-21 17:26
Return for Revision	2012-12-24 09:28
Revised	2013-03-09 02:24
Second Decision	2013-04-09 20:13
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-04-10 07:20
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-05-17 20:30
Publish the Manuscript Online	2013-05-28 09:36

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	MGMT and MLH1 methylation in Helicobacter pylori-infected children and adults
Manuscript Source	Invited Manuscript
All Author List	Marisa C Alvarez, Juliana C Santos, Nathália Maniezzo, Marcelo S Ladeira, Artur LC da Silva, Isabel CA Scaletsky, José Pedrazzoli Jr and Marcelo L Ribeiro
Funding Agency and Grant Number	Funding Agency Grant Number Fundacao de Amparo a Pesquisa do Estado de Sao Paulo 2009/01813-0 Fundacao de Amparo a Pesquisa do Estado de Sao Paulo 2008/02678-6 Conselho Nacional de Desenvolvimento Científico e Tecnológico 471088/2007-2
Corresponding Author	Marcelo L Ribeiro, PhD, Unidade Integrada de Farmacologia e Gastroenterologia, Universidade São Francisco, Av. São Francisco de Assis, 218. Jd. São José, Bragança Paulista 12916-900, SP, Brazil. marcelo.ribeiro@usf.edu.br
Key Words	Helicobacter pylori; Microsatellite instability; Promoter methylation; MLH1; MGMT; Gastric cancer
Core Tip	Gastric carcinogenesis is a multistep process that is triggered by Helicobacter pylori (H. pylori) infection and characterised by multiple genetic and epigenetic alterations, including the DNA repair genes. To date, few advances have been made to determine the time duration required for to H. pylori infection to induce such epigenetics alteration and thus potentially induce gastric carcinogenesis. The results presented in this study indicate that the methylation of the MGMT and MLH1 promoter regions might depend on the duration of infection because these methylation events were not observed in children.
Publish Date	2013-05-28 09:36
Citation	Alvarez MC, Santos JC, Maniezzo N, Ladeira MS, da Silva ALC, Scaletsky ICA, Pedrazzoli Jr J, Ribeiro ML. MGMT and MLH1 methylation in Helicobacter pylori-infected children and adults. World J Gastroenterol 2013; 19(20): 3043-3051
URL	http://www.wjgnet.com/1007-9327/full/v19/i20/3043.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i20.3043

Full Article (PDF)	WJG-19-3043.pdf
Manuscript File	1215-Review.doc
Answering Reviewers	1215-Answering reviewers.doc
Copyright License Agreement	1215-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	1215-Language certificate.pdf
Peer-review Report	1215-Peer review(s).pdf
Scientific Editor Work List	1215-Scientific editor work list.doc