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7/8/2015 9:04:00 AM | Browse: 561 | Download: 600
Publication Name World Journal of Rheumatology
Manuscript ID 12291
Country/Territory United States
2014-06-30 20:12
Peer-Review Started
2014-07-01 08:28
To Make the First Decision
2014-07-18 12:34
Return for Revision
2014-07-18 17:20
2014-08-11 08:11
Second Decision
2015-04-01 15:17
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-04-14 15:57
Articles in Press
2015-04-14 15:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-06-17 16:51
Publish the Manuscript Online
2015-07-08 09:04
ISSN 2220-3214 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Rheumatology
Manuscript Type Review
Article Title Pathogenetic mechanisms of antiphospholipid antibody production in antiphospholipid syndrome
Manuscript Source Invited Manuscript
All Author List Rohan Willis and Emilio B Gonzalez
Funding Agency and Grant Number
Corresponding author Emilio B Gonzalez, MD, FACP, FACR, Director and Chief, Division of Rheumatology, Department of Internal Medicine, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555-1165, United States. ebgonzal@utmb.edu
Keywords Antiphospholipid; Autoimmune; Infections; Antibody production; Susceptibility; Genetic; Human leukocyte antigen; Environmental; Immune tolerance
Core Tip This article reviews the most up to date theories regarding the production of pathogenic antiphospholipid antibodies (aPL) in antiphospholipid syndrome. It focuses on both the genetic and environmental aspects related to aPL production. The genetic factors highlighted include human leukocyte antigen (HLA) and non-HLA associations and where available, data linking genes to clinical manifestations is presented. The key infectious agents linked to the formation of pathogenic aPL and those mechanisms by which these agents induce a break in immune tolerance are also discussed.
Publish Date 2015-07-08 09:04
Citation Willis R, Gonzalez EB. Pathogenetic mechanisms of antiphosp¬holipid antibody production in antiphospholipid syndrome. World J Rheumatol 2015; 5(2): 59-68
Url http://www.wjgnet.com/2220-3214/full/v5/i2/59.htm
DOI http://dx.doi.org/10.5499/wjr.v5.i2.59
Full Article (PDF) WJR-5-59.pdf
Full Article (Word) WJR-5-59.doc
Manuscript File 12291-Review.docx
Answering Reviewers 12291-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form 12291-Conflict-of-interest statement.pdf
Copyright License Agreement 12291-Copyright assignment.pdf
Peer-review Report 12291-Peer-review(s).pdf
Scientific Misconduct Check 12291-Scientific misconduct check.pdf
Scientific Editor Work List 12291-Scientific editor work list.pdf