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Articles Published Processes
4/15/2015 11:01:00 AM | Browse: 1138 | Download: 1491
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Received |
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2014-07-03 10:00 |
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Peer-Review Started |
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2014-07-03 14:15 |
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To Make the First Decision |
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2014-07-21 13:01 |
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Return for Revision |
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2014-07-23 15:04 |
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Revised |
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2014-10-25 14:32 |
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Second Decision |
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2014-12-16 15:28 |
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Accepted by Journal Editor-in-Chief |
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2014-12-17 03:13 |
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Accepted by Company Editor-in-Chief |
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2014-12-22 17:04 |
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Articles in Press |
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2014-12-22 17:24 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-01-23 08:39 |
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Typeset the Manuscript |
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2015-03-25 20:11 |
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Publish the Manuscript Online |
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2015-04-15 11:01 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Basic Study |
| Article Title |
Increase in apoptosis by combination of metformin with silibinin in human colorectal cancer cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Cheng-Chia Tsai, Tang-Wei Chuang, Li-Jen Chen, Ho-Shan Niu, Kun-Ming Chung, Juei-Tang Cheng and Kao-Chang Lin |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Chi Mei Medical Center in Taiwan |
CMFHR10302(partly) |
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| Corresponding Author |
Juei-Tang Cheng, PhD, FCP, Professor, Institute of Medical Sciences, Chang Jung Christian University, Geuiren, Tainan City 71101, Taiwan. jtcheng@mail.cjcu.edu.tw |
| Key Words |
Silibinin; Metformin; COLO 205; Mammol/Lalian target of rapamycin; Apoptosis; Colorectal cancer |
| Core Tip |
Silibinin is known to provide protection against hepatotoxic stress. Silibinin has also been shown to have high efficacy against cancer cells through increased expression of the phosphatase and tensin homolog; Metformin, a well-known antidiabetic agent, has recently been reported to inhibit cancer by increasing adenosine monophosphate-activated protein kinase expression. We investigated the effect of metformin on silibinin-induced apoptosis in human colorectal cancer cells. The combined treatment of human colorectal cancer cells with silibinin and metformin may induce apoptosis at a dose that does not affect human colonic epithelial cells. This finding reveals a potential therapeutic strategy for the treatment of colorectal cancer. |
| Publish Date |
2015-04-15 11:01 |
| Citation |
Tsai CC, Chuang TW, Chen LJ, Niu HS, Chung KM, Cheng JT, Lin KC. Increase in apoptosis by combination of metformin with silibinin in human colorectal cancer cells. World J Gastroenterol 2015; 21(14): 4169-4177 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i14/4169.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i14.4169 |
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