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1/7/2015 11:06:00 AM | Browse: 1032 | Download: 1058
Publication Name World Journal of Gastroenterology
Manuscript ID 12334
Country/Territory China
Received
2014-07-03 09:40
Peer-Review Started
2014-07-03 15:32
To Make the First Decision
2014-07-21 13:00
Return for Revision
2014-07-23 15:40
Revised
2014-08-19 01:14
Second Decision
2014-10-15 12:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-10-15 17:46
Articles in Press
2014-10-15 18:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-10-25 22:01
Typeset the Manuscript
2014-12-25 21:34
Publish the Manuscript Online
2015-01-07 11:07
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Autobiography
Article Title FoxM1 overexpression promotes epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma
Manuscript Source Unsolicited Manuscript
All Author List Fan-Di Meng, Ji-Chao Wei, Kai Qu, Zhi-Xin Wang, Qi-Fei Wu, Ming-Hui Tai, Hao-Chen Liu, Rui-Yao Zhang and Chang Liu
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 30872482
National Natural Science Foundation of China 81072051
Corresponding Author Chang Liu, MD, PhD, Professor, Department of Hepatobiliary Surgery, the First Affiliated Hospital, School of Medicine, Xi’an Jiaotong University, 277 West Yan-ta Road, Xi’an 710061, Shaanxi Province, China. liuchangdoctor@163.com
Key Words Forkhead box protein M1; Epithelial-mesenchymal transition; Hepatocellular carcinoma; Snail homolog 1; E-cadherin
Core Tip Epithelial-mesenchymal transition (EMT) has emerged as a pivotal event affecting cancer invasion and metastasis, and forkhead box protein M1 (FoxM1) may regulate the EMT phenotype of pancreatic cancer cells by activation of mesenchymal cell markers. The present study demonstrated that FoxM1 plays a pivotal role in EMT and metastasis of hepatocellular carcinoma (HCC). Immunohistochemical analysis indicated that FoxM1 overexpression correlated significantly with HCC metastasis and EMT. In vitro, we found that FoxM1 plays a key role in HGF-induced EMT, and overexpression of FoxM1 could suppress E-cadherin expression and induce EMT changes by increasing snail homologue 1 expression.
Publish Date 2015-01-07 11:07
Citation Meng FD, Wei JC, Qu K, Wang ZX, Wu QF, Tai MH, Liu HC, Zhang RY, Liu C. FoxM1 overexpression promotes epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma. World J Gastroenterol 2015; 21(1): 196-213
URL http://www.wjgnet.com/1007-9327/full/v21/i1/196.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i1.196
Full Article (PDF) WJG-21-196.pdf
Full Article (Word) WJG-21-196.doc
Manuscript File 12334-Review.doc
Answering Reviewers 12334-Answering reviewers.pdf
Copyright License Agreement 12334-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 12334-Language certificate.pdf
Peer-review Report 12334-Peer reviews.pdf
Scientific Misconduct Check 12334-CrossCheck.jpg
Scientific Editor Work List 12334-Scientific editor work list.pdf