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3/16/2015 6:04:00 PM | Browse: 1197 | Download: 1338
Publication Name World Journal of Gastroenterology
Manuscript ID 12358
Country/Territory India
Received
2014-07-04 08:43
Peer-Review Started
2014-07-04 17:09
To Make the First Decision
2014-08-06 17:16
Return for Revision
2014-08-14 11:56
Revised
2014-08-28 17:30
Second Decision
2014-12-25 09:31
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-01-08 17:12
Articles in Press
2015-01-08 17:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-03-02 21:14
Publish the Manuscript Online
2015-03-16 18:04
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Biochemistry & Molecular Biology
Manuscript Type Review
Article Title To be or not to be: The host genetic factor and beyond in Helicobacter pylori mediated gastro-duodenal diseases
Manuscript Source Invited Manuscript
All Author List Dipanjana Datta De and Susanta Roychoudhury
Funding Agency and Grant Number
Corresponding Author Susanta Roychoudhury, Chief Scientist, Cancer Biology and Inflammatory Disease Division, Indian Institute of Chemical Biology, 4, Raja S.C Mullick Road, Kolkata 700032, India. susanta@iicb.res.in
Key Words Helicobacter pylori; Gastric cancer; Duodenal ulcer; Cytokine; Acid secretion
Core Tip Helicobacter pylori infection results in diverse clinical outcomes. While duodenal ulcer is characterized by hyperacidity, gastric cancer results in hypoacidity. Virulence factors of the bacteria and its own genetic heterogeneity variability does not explain the divergent spectrum of disease manifestation. In this review, we highlight the host genetic factors that are involved and elicited by the bacteria. We discuss the different association studies performed with respect to gastric cancer and duodenal ulcer and further delineate the signaling cue of these inflammatory response pathway gene products to the gastrin: somatostatin axis that is known to regulate acid secretion.
Publish Date 2015-03-16 18:04
Citation Datta De D, Roychoudhury S. To be or not to be: The host genetic factor and beyond in Helicobacter pylori mediated gastro-duodenal diseases. World J Gastroenterol 2015; 21(10): 2883-2895
URL http://www.wjgnet.com/1007-9327/full/v21/i10/2883.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i10.2883
Full Article (PDF) WJG-21-2883.pdf
Full Article (Word) WJG-21-2883.doc
Manuscript File 12358-Review.doc
Answering Reviewers 12358-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form 12358-Conflict-of-interest statement.pdf
Copyright License Agreement 12358-Copyright assignment.pdf
Peer-review Report 12358-Peer review(s).pdf
Scientific Misconduct Check 12358-CrossCheck.jpg
Scientific Editor Work List 12358-Scientific editor work list.pdf