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12/10/2015 10:35:00 AM | Browse: 418 | Download: 552
Publication Name World Journal of Gastroenterology
Manuscript ID 12417
Country/Territory China
2014-07-07 17:20
Peer-Review Started
2014-07-08 15:43
To Make the First Decision
2014-09-15 16:13
Return for Revision
2014-09-22 08:19
2014-10-23 14:31
Second Decision
2014-11-21 09:49
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-12-16 10:13
Articles in Press
2014-12-16 10:41
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-12-31 01:42
Typeset the Manuscript
2015-03-09 19:21
Publish the Manuscript Online
2015-03-19 16:57
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Urotensin II alteration and effects on cytokines in early acute liver failure
Manuscript Source Unsolicited Manuscript
All Author List Liang-Ming Liu, Liang Zhao, Dong-Yu Liang, Fang-Ping Yu, Chang-Gen Ye, Wen-Juan Tu and Tong Zhu
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81070357
National Natural Science Foundation of China 30660066
Corresponding author Liang-Ming Liu, MD, PhD, Department of Infection, Songjiang Hospital Affiliated to the First People’s Hospital, Shanghai Jiaotong University, 800 Dongchuan RD, Minhang District, Shanghai 201600, China. liuliangming@hotmail.com
Key Words Acute hepatic failure; Urotensin II; Urantide; Tumor necrosis factor α; Interleukin-1β; Mouse
Core Tip In this study, we found that increased urotensin II (UII) was an earlier event than tumor necrosis factor α (TNF-α) and interleukin (IL)-1β following lipopolysaccharide (LPS)/D-galactosamine (D-GalN) challenge, and pretreatment with urantide, an inhibitor of the UII receptor, blocked TNF-α and IL-1β increases following downregulation of UII in liver and blood at different time points after challenge. Therefore, UII may play a pivotal role in the pathogenesis and priming of acute liver failure by triggering the inflammatory cascade, and initiating and driving the early release of TNF-α and IL-1β in LPS/D-GalN-challenged mice.
Publish Date 2015-03-19 16:57
Citation Liu LM, Zhao L, Liang DY, Yu FP, Ye CG, Tu WJ, Zhu T. Effects of urotensin-Ⅱ on cytokines in early acute liver failure in mice. World J Gastroenterol 2015; 21(11): 3239-3244
Url http://www.wjgnet.com/1007-9327/full/v21/i11/3239.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i11.3239
Full Article (PDF) WJG-21-3239.pdf
Full Article (Word) WJG-21-3239.doc
Manuscript File 12417-Review.doc
Answering Reviewers 12417-Answering reviewers.pdf
Copyright License Agreement 12417-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 12417-Language certificate.PDF
Peer-review Report 12417-Peer review(s).pdf
Scientific Misconduct Check 12417-CrossCheck.jpg
Scientific Editor Work List 12417-Scientific editor work list.pdf