Publication Name	World Journal of Gastroenterology
Manuscript ID	12421
Country	Italy

Received	2014-07-07 20:54
Peer-Review Started
To Make the First Decision
Return for Revision
Revised	2014-07-07 00:00
Second Decision	2014-07-30 10:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-07-30 10:28
Articles in Press	2014-07-30 10:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-12-02 16:13
Publish the Manuscript Online	2014-12-18 17:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Locally advanced rectal cancer: The importance of a multidisciplinary approach
Manuscript Source	Invited Manuscript
All Author List	Rossana Berardi, Elena Maccaroni, Azzurra Onofri, Francesca Morgese, Mariangela Torniai, Michela Tiberi, Consuelo Ferrini and Stefano Cascinu
Funding Agency and Grant Number
Corresponding Author	Rossana Berardi, MD, Medical Oncology Unit, Università Politecnica delle Marche, Azienda Ospedaliero, Universitaria, Ospedali Riuniti Umberto I, GM Lancisi, G Salesi di Ancona, via Conca 71, 60126 Ancona, Italy. r.berardi@univpm.it
Key Words	Locally advanced rectal cancer; Neo-adjuvant treatment; Radio-chemotherapy; Surgery; Adjuvant treatment; Target drugs
Core Tip	In the last three decades, multidisciplinary treatments have significantly reduced both local and distant recurrences due to locally advanced rectal cancer, with a consensual increase in overall survival. Even if surgery still remains the mainstay of treatment, for patients with stage Ⅱ or Ⅲ rectal cancer, available data support the use of neo-adjuvant chemoradiotherapy followed by radical resection. In the neo-adjuvant setting, novel biologic agents targeting aberrant pathways in rectal carcinogenesis are currently under study. This review describes the multidisciplinary management of rectal cancer, focusing on evidences supporting this approach and on the ongoing research to improve these regimens.
Publish Date	2014-12-18 17:08
Citation	Berardi R, Maccaroni E, Onofri A, Morgese F, Torniai M, Tiberi M, Ferrini C, Cascinu S. Locally advanced rectal cancer: The importance of a multidisciplinary approach. World J Gastroenterol 2014; 20(46): 17279-17287
URL	http://www.wjgnet.com/1007-9327/full/v20/i46/17279.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i46.17279

Full Article (PDF)	WJG-20-17279.pdf
Full Article (Word)	WJG-20-17279.doc
Manuscript File	12421-Review.doc
Answering Reviewers	12421-Answering reviewers.pdf
Copyright License Agreement	12421-Copyright assignment.pdf
Peer-review Report	12421-Peer reivew.pdf
Scientific Misconduct Check	12421-CorssCheck.jpg
Scientific Editor Work List	12421-Scientific editor work list.pdf