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Articles Published Processes
2/9/2015 5:58:00 PM | Browse: 962 | Download: 1094
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Received |
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2014-07-13 12:35 |
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Peer-Review Started |
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2014-07-13 20:34 |
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To Make the First Decision |
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2014-08-15 12:17 |
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Return for Revision |
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2014-08-20 13:10 |
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Revised |
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2014-08-28 10:33 |
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Second Decision |
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2014-09-30 10:05 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2014-09-30 10:35 |
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Articles in Press |
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2014-09-30 10:58 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2014-10-16 15:06 |
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Typeset the Manuscript |
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2015-01-20 19:53 |
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Publish the Manuscript Online |
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2015-02-09 17:58 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Autobiography |
| Article Title |
MiR-21/RASA1 axis affects malignancy of colon cancer cells via RAS pathways
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Bo Gong, Wan-Wei Liu, Wen-Jing Nie, Dong-Feng Li, Zi-Jun Xie, Chao Liu, Yan-Hui Liu, Ping Mei and Zi-Jun Li |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81272770 |
| Guangdong Natural Science Foundation |
S2013020012746 |
| Foundation of Guangdong Provincial Department of Science and Technology |
2012A030400018 |
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| Corresponding Author |
Zi-Jun Li, MD, PhD, Professor, Department of Gastroenterology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, Guangdong Province, China. zijunli2005@aliyun.com |
| Key Words |
Colon cancer; miR-21; RAS; RASA1; RAS signaling pathways |
| Core Tip |
In this work, we confirmed RAS p21 GTPase activating protein 1 (RASA1) as an miR-21 target and assessed the role of the miR-21/RASA1 axis in colon cancer cells. Our data suggested that miR-21 activated the RAS signaling pathways by down-regulating RASA1 expression, and it played an important role in promoting cell proliferation, anti-apoptosis and tumor cell formation. |
| Publish Date |
2015-02-09 17:58 |
| Citation |
Gong B, Liu WW, Nie WJ, Li DF, Xie ZJ, Liu C, Liu YH, Mei P, Li ZJ. MiR-21/RASA1 axis affects malignancy of colon cancer cells via RAS pathways. World J Gastroenterol 2015; 21(5): 1488-1497 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i5/1488.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i5.1488 |
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