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Publication Name World Journal of Gastroenterology
Manuscript ID 12513
Country/Territory China
2014-07-13 12:35
Peer-Review Started
2014-07-13 20:34
To Make the First Decision
2014-08-15 12:17
Return for Revision
2014-08-20 13:10
2014-08-28 10:33
Second Decision
2014-09-30 10:05
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-09-30 10:35
Articles in Press
2014-09-30 10:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-10-16 15:06
Typeset the Manuscript
2015-01-20 19:53
Publish the Manuscript Online
2015-02-09 17:58
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Autobiography
Article Title MiR-21/RASA1 axis affects malignancy of colon cancer cells via RAS pathways
Manuscript Source Unsolicited Manuscript
All Author List Bo Gong, Wan-Wei Liu, Wen-Jing Nie, Dong-Feng Li, Zi-Jun Xie, Chao Liu, Yan-Hui Liu, Ping Mei and Zi-Jun Li
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81272770
Guangdong Natural Science Foundation S2013020012746
Foundation of Guangdong Provincial Department of Science and Technology 2012A030400018
Corresponding Author Zi-Jun Li, MD, PhD, Professor, Department of Gastroenterology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, Guangdong Province, China. zijunli2005@aliyun.com
Key Words Colon cancer; miR-21; RAS; RASA1; RAS signaling pathways
Core Tip In this work, we confirmed RAS p21 GTPase activating protein 1 (RASA1) as an miR-21 target and assessed the role of the miR-21/RASA1 axis in colon cancer cells. Our data suggested that miR-21 activated the RAS signaling pathways by down-regulating RASA1 expression, and it played an important role in promoting cell proliferation, anti-apoptosis and tumor cell formation.
Publish Date 2015-02-09 17:58
Citation Gong B, Liu WW, Nie WJ, Li DF, Xie ZJ, Liu C, Liu YH, Mei P, Li ZJ. MiR-21/RASA1 axis affects malignancy of colon cancer cells via RAS pathways. World J Gastroenterol 2015; 21(5): 1488-1497
URL http://www.wjgnet.com/1007-9327/full/v21/i5/1488.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i5.1488
Full Article (PDF) WJG-21-1488.pdf
Full Article (Word) WJG-21-1488.doc
Manuscript File 12513-Review.doc
Answering Reviewers 12513-Answering reviewers.pdf
Copyright License Agreement 12513-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 12513-Language certificate.pdf
Peer-review Report 12513-Peer review.pdf
Scientific Misconduct Check 12513-CorssCheck.jpg
Scientific Editor Work List 12513-Scientific editor work list.pdf