Publication Name	World Journal of Pharmacology
Manuscript ID	12562
Country	India

Received	2014-07-15 08:07
Peer-Review Started	2014-07-15 17:09
To Make the First Decision	2014-08-28 14:50
Return for Revision	2014-08-31 16:14
Revised	2014-10-09 02:45
Second Decision	2015-02-03 19:25
Accepted by Journal Editor-in-Chief	2015-02-05 18:15
Accepted by Company Editor-in-Chief	2015-02-11 15:35
Articles in Press	2015-02-11 15:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-03-03 18:33
Publish the Manuscript Online	2015-03-12 19:39

ISSN	2220-3192 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Pharmacology & Pharmacy
Manuscript Type	Review
Article Title	Role of opioid receptor heterodimerization in pain modulation and tolerance development
Manuscript Source	Invited Manuscript
All Author List	Annu Mudgal and Santosh Pasha
Funding Agency and Grant Number	Funding Agency Grant Number Council of Scientific and Industrial Research
Corresponding Author	Dr. Santosh Pasha, Peptide Synthesis Laboratory, CSIR/Institute of Genomics and Integrative Biology, Mall Road, Delhi 110007, India. spasha@igib.res.in
Key Words	Opioid receptors; Receptor heterodimers; G-protein coupled receptors oligomerization; G protein coupled receptors; Opioid tolerance; G-protein coupled receptors; Allosteric regulation; Antinociception
Core Tip	Endogenous opioid peptides are known for their analgesic effects. However their analgesic effect is downplayed by the side-effect of tolerance development. To maintain homeostasis to their effect, other endogenous anti-opioid peptides works parallel to it. The present work highlights the role of anti-opiates in development of tolerance to opiate drugs.
Publish Date	2015-03-12 19:39
Citation	Mudgal A, Pasha S. Role of opioid receptor heterodimerization in pain modulation and tolerance development. World J Pharmacol 2015; 4(1): 144-159
URL	http://www.wjgnet.com/2220-3192/full/v4/i1/144.htm
DOI	http://dx.doi.org/10.5497/wjp.v4.i1.144

Full Article (PDF)	WJP-4-144.pdf
Full Article (Word)	WJP-4-144.doc
Manuscript File	12562-Review.docx
Answering Reviewers	12562-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	12562-Conflict-of-interest statement.pdf
Copyright License Agreement	12562-Copyright assignment.pdf
Peer-review Report	12562-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	12562-Journal Editor-in-Chief Review Report.pdf
Scientific Misconduct Check	12562-Scientific misconduct check.pdf
Scientific Editor Work List	12562-Scientific editor work list.pdf