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Articles Published Processes
2/11/2015 5:56:00 PM | Browse: 1151 | Download: 1103
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Received |
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2014-07-19 12:24 |
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Peer-Review Started |
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2014-07-20 10:41 |
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To Make the First Decision |
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2014-08-15 12:16 |
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Return for Revision |
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2014-08-20 13:25 |
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Revised |
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2014-08-29 19:58 |
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Second Decision |
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2014-10-15 07:33 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2014-10-15 07:48 |
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Articles in Press |
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2014-10-15 08:22 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2014-10-31 19:51 |
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Typeset the Manuscript |
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2015-01-26 18:25 |
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Publish the Manuscript Online |
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2015-02-11 17:56 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Autobiography |
| Article Title |
In vitro identification of nonalcoholic fatty liver disease-related protein hnRNPM
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jun-ichi Takino, Kentaro Nagamine, Masayoshi Takeuchi and Takamitsu Hori |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Japan Society for the Promotion of Science |
22300264 |
| Japan Society for the Promotion of Science |
25282029 |
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| Corresponding Author |
Masayoshi Takeuchi, PhD, Department of Advanced Medicine, Medical Research Institute, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku, Ishikawa 920-0293, Japan. takeuchi@kanazawa-med.ac.jp |
| Key Words |
Advanced glycation end-products; Fructose; Glycation; Glyceraldehyde; Heterogeneous nuclear ribonucleoprotein M; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis |
| Core Tip |
Excessive intake of fructose contributes to the development of nonalcoholic fatty liver disease and to the progression of the disease to nonal?coholic steatohepatitis. Fructose is metabolized to glyceraldehyde, which is a precursor of glyceraldehyde-derived advanced glycation end-products (Glycer-AGEs). We showed that intracellular Glycer-AGEs were formed in the presence of high concentrations of fructose. Additionally, heterogeneous nuclear ribonucleoprotein M (hnRNPM) was identified as one of the target proteins for glycation. These results suggest that the glyceraldehyde-modified hnRNPM resulting from the exposure of the cells to high concentrations of fructose, alters gene expression and causes adverse effects in hepatocytes. |
| Publish Date |
2015-02-11 17:56 |
| Citation |
Takino J, Nagamine K, Takeuchi M, Hori T. In vitro identification of nonalcoholic fatty liver disease-related protein hnRNPM. World J Gastroenterol 2015; 21(6): 1784-1793 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i6/1784.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i6.1784 |
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