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3/30/2015 5:46:00 PM | Browse: 614 | Download: 539
Publication Name World Journal of Gastroenterology
Manuscript ID 12678
Country/Territory China
2014-07-21 16:02
Peer-Review Started
2014-07-21 18:57
To Make the First Decision
2014-08-15 12:12
Return for Revision
2014-08-19 16:27
2014-09-15 18:46
Second Decision
2014-10-15 07:44
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-10-15 08:17
Articles in Press
2014-10-15 08:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-10-31 09:41
Typeset the Manuscript
2015-03-17 20:38
Publish the Manuscript Online
2015-03-30 14:23
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Virology
Manuscript Type Basic Study
Article Title High persistence rate of hepatitis B virus in a hydrodynamic injection-based transfection model in C3H/HeN mice
Manuscript Source Unsolicited Manuscript
All Author List Xiu-Hua Peng, Xiao-Nan Ren, Li-Xiang Chen, Bi-Sheng Shi, Chun-Hua Xu, Zhong Fang, Xue Liu, Jie-Liang Chen, Xiao-Nan Zhang, Yun-Wen Hu and Xiao-Hui Zhou
Funding Agency and Grant Number
Funding Agency Grant Number
Shanghai Municipal Fund for Science and Technology Development 13140902200
Shanghai Municipal Fund for Science and Technology Development 12140900300
National Basic Research Program of China(973 Program) 2012CB519005
Corresponding author Xiao-Hui Zhou, MD, PhD, Associate Professor, Shanghai Public Health Clinical Center, Key Laboratory of Medical Molecular Virology, Ministry of Education and Health, Fudan University, 2901 Caolang Road, Jin Shan District, Shanghai 201508, China. zhouxiaohui@shaphc.org
Key Words Hepatitis B virus; Hydrodynamic injection; Viral persistence; Liver; Mouse
Core Tip In the classic hepatitis B virus (HBV) hydrodynamic injection (HI) model using C57BL/6 mice, only about 30% of the injected mice carried HBV for more than 12 wk. Here we injected the pAAV-HBV1.2 plasmid into C3H/HeN mice and observed that the hepatitis B surface antigen, hepatitis B e antigen and viral DNA persisted even up to 46 wk in about 90% of the hydrodynamically injected mice. Applying interferon-? or entecavir in this HI model decreased HBV DNA in vivo. Hence, C3H/HeN is a suitable mouse strain for the persistent HBV HI model, which might be useful for chronic hepatitis B research and therapeutic drug development.
Publish Date 2015-03-30 14:23
Citation Peng XH, Ren XN, Chen LX, Shi BS, Xu CH, Fang Z, Liu X, Chen JL, Zhang XN, Hu YW, Zhou XH. High persistence rate of hepatitis B virus in a hydrodynamic injection-based transfection model in C3H/HeN mice. World J Gastroenterol 2015; 21(12): 3527-3536
Url http://www.wjgnet.com/1007-9327/full/v21/i12/3527.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i12.3527
Full Article (PDF) WJG-21-3527.pdf
Full Article (Word) WJG-21-3527.doc
Manuscript File 12678-Review.docx
Answering Reviewers 12678-Answering reviewers.pdf
Copyright License Agreement 12678-Copyright assignment.pdf
Peer-review Report 12678-Peer review(s).pdf
Scientific Misconduct Check 12678-CrossCheck.jpg
Scientific Editor Work List 12678-Scientific editor work list.pdf