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Publication Name World Journal of Hepatology
Manuscript ID 12723
Country/Territory South Korea
2014-07-23 20:36
Peer-Review Started
2014-07-25 20:34
To Make the First Decision
2014-08-14 14:57
Return for Revision
2014-08-15 10:00
2014-08-27 07:50
Second Decision
2014-10-16 15:07
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-10-16 15:41
Articles in Press
2014-10-16 15:41
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-11-20 09:16
Publish the Manuscript Online
2014-11-20 19:46
ISSN 1948-5182 (online)
Open Access
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, Research and Experimental
Manuscript Type Topic Highlights
Article Title Pathogenesis and therapeutic approaches for non-alcoholic fatty liver disease
Manuscript Source Invited Manuscript
All Author List Hye-jin Yoon and Bong Soo Cha
Funding Agency and Grant Number
Corresponding Author Bong Soo Cha, MD, PhD, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemoon-gu, Seoul 120-752, South Korea. bscha@yuhs.ac
Key Words Non-alcoholic fatty liver disease; Insulin resistance; Drugs; Pathogenesis
Core Tip In this review, we summarize the pathogenesis underlying the progression of hepatic steatosis to steatohepatitis and cirrhosis. We also discuss established drugs that are already being used to treat non-alcoholic fatty liver disease, in addition to newly discovered agents, with respect to their mechanisms of drug action, focusing mainly on hepatic insulin resistance. As well, we review clinical data that demonstrate the efficacy of these drugs, together with improvements in biochemical or histological parameters. Furthermore, we introduced future treatment option for non-alcoholic fatty liver disease.
Publish Date 2014-11-20 19:46
Citation Yoon HJ, Cha BS. Pathogenesis and therapeutic approaches for non-alcoholic fatty liver disease. World J Hepatol 2014; 6(11): 800-811
URL http://www.wjgnet.com/1948-5182/full/v6/i11/800.htm
DOI http://dx.doi.org/10.4254/wjh.v6.i11.800
Full Article (PDF) WJH-6-800.pdf
Full Article (Word) WJH-6-800.doc
Manuscript File 12723-Review.doc
Answering Reviewers 12723-Answering reviewers.pdf
Copyright License Agreement 12723-Copyright assignment.pdf
Peer-review Report 12723-Peer review(s).pdf
Scientific Misconduct Check 12723-CrossCheck.jpg
Scientific Editor Work List 12723-Scientific editor work list.pdf