Publication Name	World Journal of Diabetes
Manuscript ID	12732
Country	Japan

Received	2014-07-24 09:17
Peer-Review Started	2014-07-24 17:01
To Make the First Decision	2014-08-14 14:57
Return for Revision	2014-08-15 11:06
Revised	2014-08-17 11:03
Second Decision	2014-11-21 08:38
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-12-01 14:04
Articles in Press	2014-12-01 14:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-01-15 18:56
Publish the Manuscript Online	2015-01-31 14:38

ISSN	1948-9358 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Medicine, General & Internal
Manuscript Type	Review
Article Title	β-cell dysfunction: Its critical role in prevention and management of type 2 diabetes
Manuscript Source	Invited Manuscript
All Author List	Yoshifumi Saisho
Funding Agency and Grant Number
Corresponding Author	Yoshifumi Saisho, MD, PhD, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. ysaisho@z5.keio.jp
Key Words	β-cell; Insulin secretion; Type 2 diabetes; Prevention; Treatment
Core Tip	Recent studies have revealed that a deficit of β-cell functional mass is an essential component of the pathophysiology of type 2 diabetes (T2DM). Β-cell dysfunction is present at the diagnosis of T2DM and progressively worsens with disease duration. Β-cell dysfunction is associated with worsening of glycemic control and treatment failure; thus, it is important to preserve or recover β-cell functional mass in the management of T2DM. This review summarizes the current knowledge on β-cell functional mass in T2DM and discusses the treatment strategy for T2DM.
Publish Date	2015-01-31 14:38
Citation	Saisho Y. β-cell dysfunction: Its critical role in prevention and management of type 2 diabetes. World J Diabetes 2015; 6(1): 109-124
URL	http://www.wjgnet.com/1948-9358/full/v6/i1/109.htm
DOI	http://dx.doi.org/10.4239/wjd.v6.i1.109

Full Article (PDF)	WJD-6-109.pdf
Full Article (Word)	WJD-6-109.doc
Manuscript File	12732-Review.docx
Answering Reviewers	12732-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	12732-Conflict of interest.pdf
Copyright License Agreement	12732-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	Recommendation letter for Dr Saisho 16.8.14.pdf
Peer-review Report	12732-Peer review(s).pdf
Scientific Misconduct Check	12732-CrossCheck.jpg
Scientific Editor Work List	12732-Scientific editor work list.pdf