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3/20/2015 10:48:00 AM | Browse: 1049 | Download: 1137
Publication Name World Journal of Stem Cells
Manuscript ID 12825
Country/Territory South Korea
Received
2014-07-27 15:06
Peer-Review Started
2014-07-27 23:15
To Make the First Decision
2014-08-28 15:08
Return for Revision
2014-09-01 17:25
Revised
2014-09-25 10:06
Second Decision
2014-11-03 16:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-11-03 17:11
Articles in Press
2014-11-03 17:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-02-12 12:06
Publish the Manuscript Online
2015-03-20 10:47
ISSN 1948-0210 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Biochemistry & Molecular Biology
Manuscript Type Review
Article Title Mitochondria as therapeutic targets for cancer stem cells
Manuscript Source Invited Manuscript
All Author List In Sung Song, Jeong Yu Jeong, Seung Hun Jeong, Hyoung Kyu Kim, Kyung Soo Ko, Byoung Doo Rhee, Nari Kim and Jin Han
Funding Agency and Grant Number
Funding Agency Grant Number
Priority Research Centers Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology 2010-0020224
Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology 2012R1A1A2041700
Corresponding Author Jin Han, MD, PhD, National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, 633-165 Gaegeum-dong, Busanjin-gu, Busan 614-735, South Korea. phyhanj@inje.ac.kr
Key Words Cancer stem cells; Mitochondria; Relapsed and refractory cancer; Therapeutic target; Mitochondrial energy metabolism
Core Tip This review is devoted to the analysis of mitochondrial function as a therapeutic target to induce cell death in cancer stem cells (CSCs). In particular, we focused on the differences in energy metabolism and features between CSC and non-CSC mitochondria, and between CSCs and normal stem cells. We described the roles of mitochondria that may make CSCs more susceptible to anti-cancer treatment and apoptosis, and how these may be useful to develop novel strategies for cancer treatment, such as through combined therapy with specific mitochondrial-targeting drugs.
Publish Date 2015-03-20 10:47
Citation Song IS, Jeong JY, Jeong SH, Kim HK, Ko KS, Rhee BD, Kim N, Han J. Mitochondria as therapeutic targets for cancer stem cells. World J Stem Cells 2015; 7(2): 418-427
URL http://www.wjgnet.com/1948-0210/full/v7/i2/418.htm
DOI http://dx.doi.org/10.4252/wjsc.v7.i2.418
Full Article (PDF) WJSC-7-418.pdf
Full Article (Word) WJSC-7-418.doc
Manuscript File 12825-Review.docx
Answering Reviewers 12825-Answering reviewers.pdf
Copyright License Agreement 12825-Copyright assignment.pdf
Peer-review Report 12825-Peer review(s).pdf
Scientific Misconduct Check 12825-CrossCheck.jpg
Scientific Editor Work List 12825-Scientific editor work list.pdf