Publication Name	World Journal of Clinical Cases
Manuscript ID	12834
Country

Received	2014-07-28 10:15
Peer-Review Started	2014-07-28 18:20
To Make the First Decision	2014-09-16 10:59
Return for Revision	2014-09-18 10:31
Revised	2014-10-09 00:00
Second Decision	2014-10-29 17:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-10-29 18:48
Articles in Press	2014-10-29 18:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-01-22 09:28
Publish the Manuscript Online	2015-02-05 16:28

ISSN	2307-8960 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Nutrition & Dietetics
Manuscript Type	Minireviews
Article Title	Review on microbiota and effectiveness of probiotics use in older
Manuscript Source	Invited Manuscript
All Author List	Mariangela Rondanelli, Attilio Giacosa, Milena Anna Faliva, Simone Perna, Francesca Allieri and Anna Maria Castellazzi
Funding Agency and Grant Number
Corresponding Author	Mariangela Rondanelli, Professor, Department of Public Health, Experimental and Forensic Medicine, School of Medicine, University of Pavia, Azienda di Servizi alla Persona di Pavia, Pavia 27100, Italy. mariangela.rondanelli@unipv.it
Key Words	Microbiota; Elderly; Probiotics; Antibiotic-associated diarrhea; Constipation
Core Tip	The intestinal microbiota of elderly manifested a reduction in the diversity, characterized by a large interindividual variability, with lower numbers of Firmicutes, Bifidobacteria, Clostridium cluster XIV, Faecalibacterium Prausnitzii, Blautia coccoides-Eubacterium rectal and higher in Enterobacteriaceae and Bacteroidetes. These derangements may not necessarily aging-correlated, but they can be consequent to the decline of general state of health, malnutrition and increased use of drugs. As regards probiotics, the main double-blind studies in the elderly have shown that use is safe and could represent an interesting support to reduced frequency and/or duration of antibiotic-associated diarrhea, other than to help for constipation.
Publish Date	2015-02-05 16:28
Citation	Rondanelli M, Giacosa A, Faliva MA, Perna S, Allieri F, Castellazzi AM. Review on microbiota and effectiveness of probiotics use in older. World J Clin Cases 2015; 3(2): 156-162
URL	http://www.wjgnet.com/2307-8960/full/v3/i2/156.htm
DOI	http://dx.doi.org/10.12998/wjcc.v3.i2.156

Full Article (PDF)	WJCC-3-156.pdf
Full Article (Word)	WJCC-3-156.doc
Manuscript File	12834-Review.doc
Answering Reviewers	12834-Answering reviewers.pdf
Copyright License Agreement	12834-Copyright assignment.pdf
Peer-review Report	12834-Peer review(s).pdf
Scientific Misconduct Check	12834-CrossCheck.jpg
Scientific Editor Work List	12834-Scientific editor work list.pdf