| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Autobiography |
| Article Title |
Significance of platelet count and platelet-based models for hepatocellular carcinoma recurrence
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Qing Pang, Jing-Yao Zhang, Xin-Sen Xu, Si-Dong Song, Kai Qu, Wei Chen, Yan-Yan Zhou, Run-Chen Miao, Su-Shun Liu, Ya-Feng Dong and Chang Liu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
30872482 |
| National Natural Science Foundation of China |
81072051 |
|
| Corresponding Author |
Chang Liu, MD, PhD, Professor, Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, No. 277 West Yan-ta Road, Xi’an 710061, Shaanxi Province, China. liuchangdoctor@163.com |
| Key Words |
Alkaline phosphatase; Alpha-fetoprotein; Aspartate aminotransferase; Blood platelets; Hepatocellular carcinoma; Recurrence |
| Core Tip |
The high risk of postoperative recurrence is one of the greatest problems plaguing potential curative treatment for hepatocellular carcinoma (HCC). Although several prognostic models have been proposed for HCC, these indices mainly focus on non-modifiable tumor characteristics. In contrast, platelet count is an improvable variable, and there are numerous platelet-based models associated with cirrhosis and HCC formation. We found that platelet count and nearly half of the established platelet-related models were independently associated with postoperative recurrence. We also demonstrated different risk factors between early and late recurrences, with platelets more likely to influence late recurrence. |
| Publish Date |
2015-05-18 17:02 |
| Citation |
Pang Q, Zhang JY, Xu XS, Song SD, Qu K, Chen W, Zhou YY, Miao RC, Liu SS, Dong YF, Liu C. Significance of platelet count and platelet-based models for hepatocellular carcinoma recurrence. World J Gastroenterol 2015; 21(18): 5607-5621 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i18/5607.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i18.5607 |
