Publication Name	World Journal of Pharmacology
Manuscript ID	12923
Country	Argentina

Received	2014-07-29 08:52
Peer-Review Started	2014-07-29 21:52
To Make the First Decision	2014-09-16 10:48
Return for Revision	2014-09-18 12:30
Revised	2014-10-02 21:01
Second Decision	2014-11-21 12:17
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-12-01 13:54
Articles in Press	2014-12-01 13:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-03-02 17:22
Publish the Manuscript Online	2015-03-12 19:39

ISSN	2220-3192 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Hepatocellular carcinoma and multidrug resistance: Past, present and new challenges for therapy improvement
Manuscript Source	Invited Manuscript
All Author List	María L Cuestas, José R Oubiña and Verónica L Mathet
Funding Agency and Grant Number
Corresponding Author	Verónica L Mathet, PhD, Instituto de Investigaciones en Microbiología y Parasitología Médica (IMPaM, UBA-CONICET), Facultad de Medicina, Universidad de Buenos Aires-Consejo Nacional de Investigaciones Científicas y Técnicas, piso 11 (C1121ABG), Paraguay 2155, Buenos Aires, Argentina. vmathet@yahoo.com
Key Words	Hepatocellular carcinoma; Therapy; Multidrug resistance; Drug delivery systems; Liver targeting
Core Tip	Hepatocellular carcinoma (HCC) is the most frequent malignancy of the liver. Despite the advances in early detection and treatment, this disorder still has a poor prognosis. This manuscript reviews the ongoing knowledge regarding the etiology and molecular mechanisms implicated in HCC development and the therapeutic strategies for the management of this malignancy. Finally, the development of effective delivery systems of antitumor drugs able to target the liver parenchyma as well as the prospects in the development of a more efficient drug therapy to overcome multidrug resistance are also examined.
Publish Date	2015-03-12 19:39
Citation	Cuestas ML, Oubiña JR, Mathet VL. Hepatocellular carcinoma and multidrug resistance: Past, present and new challenges for therapy improvement. World J Pharmacol 2015; 4(1): 96-116
URL	http://www.wjgnet.com/2220-3192/full/v4/i1/96.htm
DOI	http://dx.doi.org/10.5497/wjp.v4.i1.96

Full Article (PDF)	WJP-4-96.pdf
Full Article (Word)	WJP-4-96.doc
Manuscript File	12923-Review.doc
Answering Reviewers	12923-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	12923-Conflict-of-interest statement.pdf
Copyright License Agreement	12923-Copyright assignment.pdf
Peer-review Report	12923-Peer review(s).pdf
Scientific Misconduct Check	12923-CrossCheck.jpg
Scientific Editor Work List	12923-Scientific editor work list.pdf