Publication Name	World Journal of Stem Cells
Manuscript ID	12927
Country	United States

Received	2014-07-29 08:39
Peer-Review Started	2014-07-29 21:14
To Make the First Decision	2014-09-04 09:27
Return for Revision	2014-09-04 17:13
Revised	2014-09-09 23:30
Second Decision	2014-09-17 14:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-09-17 14:30
Articles in Press	2014-09-17 14:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-09-25 15:58
Publish the Manuscript Online	2014-09-28 14:56

ISSN	1948-0210 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Cell Biology
Manuscript Type	Review
Article Title	Mesenchymal stem cells: Emerging mechanisms of immunomodulation and therapy
Manuscript Source	Invited Manuscript
All Author List	Justin D Glenn and Katharine A Whartenby
Funding Agency and Grant Number
Corresponding Author	Katharine A Whartenby, PhD, Departments of Neurology and Oncology, Johns Hopkins School of Medicine, 601 N. Wolfe Street, Baltimore, Maryland, MD 21287, United States. whartenby@jhmi.edu
Key Words	Mesenchymal stem cell; Immunosuppression; Immunogenic; Autoimmunity; Cell-based therapy
Core Tip	Mesenchymal stem cells (MSCs) comprise a mixture of different stromal cell types that display remarkable pleiotropic properties, including those of anti-apoptosis, angiogenesis, growth factor production, anti-fibrosis, and chemo-attraction. It is because of these diverse biological properties that these cells have been intensively studied in the hopes of their utilization as a platform of cellular therapy in disease settings. Early experimental and preclinical studies focused on their stem cell renewal, differentiation, and regenerative properties for potential use in degenerative diseases of mesenchymal origin. Afterwards, MSCs were found to increase the success of bone marrow transplantation, reduce rejection of engrafted tissues, and display remarkable anti-inflammatory properties. Currently, much work centers on the immune-modulatory facets of MSCs, especially in reducing inflammation and suppressing immune cell function in preclinical injury and autoimmune disease settings. However, emerging reports suggest a multifunctional quality to MSC immune-modulation. This review dissects MSC manipulation of immune responses, which result in either immunosuppression or immuno-stimulation.
Publish Date	2014-09-28 14:56
Citation	Glenn JD, Whartenby KA. Mesenchymal stem cells: Emerging mechanisms of immunomodulation and therapy. World J Stem Cells 2014; 6(5): 526-539
URL	http://www.wjgnet.com/1948-0210/full/v6/i5/526.htm
DOI	http://dx.doi.org/10.4252/wjsc.v6.i5.526

Full Article (PDF)	WJSC-6-526.pdf
Full Article (Word)	WJSC-6-526.doc
Manuscript File	12927-Review.docx
Answering Reviewers	12927-Answering reviewers.pdf
Copyright License Agreement	12927-Copyright assignment.pdf
Peer-review Report	12927-Peer review(s).pdf
Scientific Misconduct Check	12927-CrossCheck.jpg
Scientific Editor Work List	12927-Scientific editor work list.pdf