Publication Name	World Journal of Pharmacology
Manuscript ID	12938
Country	Spain

Received	2014-07-29 08:14
Peer-Review Started	2014-07-29 18:32
To Make the First Decision	2014-10-14 17:56
Return for Revision	2014-10-16 19:04
Revised	2014-11-07 04:16
Second Decision	2014-11-21 12:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-12-01 13:57
Articles in Press	2014-12-01 13:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-03-03 09:25
Publish the Manuscript Online	2015-03-12 19:39

ISSN	2220-3192 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Microbiology
Manuscript Type	Review
Article Title	Carbapenemases: A worldwide threat to antimicrobial therapy
Manuscript Source	Invited Manuscript
All Author List	José Miguel Sahuquillo-Arce, Alicia Hernández-Cabezas, Fernanda Yarad-Auad, Elisa Ibáñez-Martínez, Patricia Falomir-Salcedo and Alba Ruiz-Gaitán
Funding Agency and Grant Number
Corresponding Author	José Miguel Sahuquillo-Arce, MD, Grupo de investigación de infecciones respiratorias, Instituto de Investigación Sanitaria - Fundación para la Investigación Hospital La Fe., Bulevar Sur, s/n, Hospital U. y P. La Fe, Torre A, Planta 6ª, 46026 Valencia, Spain. wadjur@hotmail.com
Key Words	Carbapenemases; Origin; Epidemiology; Evolution; Multi-Drug-resistant bacteria
Core Tip	Carbapenemase-producing bacteria were a rare curiosity 15 years ago, as these bacteria were primarily detected in hospital settings. However, now carbapenemase-producing bacteria are observed in farms, companion or wild animals and even in distant glaciers, becoming an epidemic. The relevance this subject has acquired can be easily demonstrated through a search in any medical database; more than 1500 articles have been published depicting the exponential isolation of these bacteria since 1990, with an alarming acceleration in the last seven years.
Publish Date	2015-03-12 19:39
Citation	Sahuquillo-Arce JM, Hernández-Cabezas A, Yarad-Auad F, Ibáñez-Martínez E, Falomir-Salcedo P, Ruiz-Gaitán A. Carbapenemases: A worldwide threat to antimicrobial therapy. World J Pharmacol 2015; 4(1): 75-95
URL	http://www.wjgnet.com/2220-3192/full/v4/i1/75.htm
DOI	http://dx.doi.org/10.5497/wjp.v4.i1.75

Full Article (PDF)	WJP-4-75.pdf
Full Article (Word)	WJP-4-75.doc
Manuscript File	12938-Review.docx
Answering Reviewers	12938-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	12938-Conflict-of-interest statement.pdf
Copyright License Agreement	12938-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	12938-Language certificate.pdf
Peer-review Report	12938-Peer review(s).pdf
Scientific Misconduct Check	12938-CrossCheck.jpg
Scientific Editor Work List	12938-Scientific editor work list.pdf