Publication Name	World Journal of Hepatology
Manuscript ID	12995
Country	Spain

Received	2014-08-01 09:29
Peer-Review Started	2014-08-01 22:04
To Make the First Decision	2014-08-28 14:45
Return for Revision	2014-09-04 15:00
Revised	2015-01-31 22:48
Second Decision	2015-02-10 16:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-02-12 14:37
Articles in Press	2015-02-12 14:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-04-29 17:15
Publish the Manuscript Online	2015-05-20 16:43

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Bone changes in alcoholic liver disease
Manuscript Source	Invited Manuscript
All Author List	Emilio González-Reimers, Geraldine Quintero-Platt, Eva Rodríguez-Rodríguez, Antonio Martínez-Riera, Julio Alvisa-Negrín and Francisco Santolaria-Fernández
Funding Agency and Grant Number
Corresponding Author	Dr. Emilio González-Reimers, PhD, Servicio de Medicina Interna, Hospital Universitario de Canarias, Universidad de La Laguna, Ofra s/n, Tenerife, 38320 Canary Islands, Spain. egonrey@ull.es
Key Words	Alcoholism; Liver disease; Osteoporosis; Vitamin D; Bone fractures
Core Tip	Alcoholism is associated with an increased risk of fractures and a higher prevalence of bone disease, particularly osteoporosis. While ethanol has a direct toxic effect on bone, other factors such as malnutrition, increased levels of proinflammatory cytokines, alcoholic myopathy and neuropathy, and an increased risk of trauma also contribute to bone disease. It is noteworthy that alterations in bone metabolism have been described as reversible so that the mainstay of treatment should be alcohol abstinence. Treatment with vitamin D, calcium, and biphosphonates have been studied in the general population but further trials are needed in alcoholic patients.
Publish Date	2015-05-20 16:43
Citation	González-Reimers E, Quintero-Platt G, Rodríguez-Rodríguez E, Martínez-Riera A, Alvisa-Negrín J, Santolaria-Fernández F. Bone changes in alcoholic liver disease. World J Hepatol 2015; 7(9): 1258-1264
URL	http://www.wjgnet.com/1948-5182/full/v7/i9/1258.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i9.1258

Full Article (PDF)	WJH-7-1258.pdf
Full Article (Word)	WJH-7-1258.doc
Manuscript File	12995-Review.doc
Answering Reviewers	12995-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	12995-Conflict-of-interest statement.pdf
Copyright License Agreement	12995-Copyright assignment.pdf
Peer-review Report	12995-Peer-review(s).pdf
Scientific Misconduct Check	12995-Scientific misconduct check.pdf
Scientific Editor Work List	12995-Scientific editor work list.pdf