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7/8/2015 9:04:00 AM | Browse: 888 | Download: 1127
Publication Name World Journal of Rheumatology
Manuscript ID 13041
Country/Territory Spain
Received
2014-08-03 09:58
Peer-Review Started
2014-08-03 11:05
To Make the First Decision
2014-08-28 14:44
Return for Revision
2014-09-03 15:32
Revised
2014-09-08 00:45
Second Decision
2015-03-20 11:50
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-04-07 15:44
Articles in Press
2015-04-07 15:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-06-23 12:13
Publish the Manuscript Online
2015-07-08 09:04
ISSN 2220-3214 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Rheumatology
Manuscript Type Minireviews
Article Title Safety of biologic therapies during pregnancy in women with rheumatic disease
Manuscript Source Invited Manuscript
All Author List Natalia Mena-Vazquez, Sara Manrique-Arija and Antonio Fernandez-Nebro
Funding Agency and Grant Number
Corresponding Author Antonio Fernandez-Nebro, PhD, Department of Rheumatology, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Universidad de Málaga, Plaza del Hospital Civil s/nPabellón 7 – 2ª planta, 29009 Málaga, Spain. afernandezn@uma.es
Key Words Pregnancy; Biologic therapy; Monoclonal antibodies; Rheumatic diseases; Safety
Core Tip Biologic therapy during pregnancy is an important topic that remains unresolved. Most of the monoclonal antibodies are actively transferred to fetal circulation using the neonatal Fc receptor. Some evidence suggests that differences may exist between drugs relating to safety associated with structure and the capacity to cross the placenta, but we are not aware of any study that supports this statement. Although the clinical data to date are promising, no firm conclusions can be drawn about the safety of biologic drugs during pregnancy, and, without further evidence, guidelines that suggest these drugs should be avoided at the time of conception cannot yet be changed.
Publish Date 2015-07-08 09:04
Citation Mena-Vazquez N, Manrique-Arija S, Fernandez-Nebro A. Safety of biologic therapies during pregnancy in women with rheumatic disease. World J Rheumatol 2015; 5(2): 82-89
URL http://www.wjgnet.com/2220-3214/full/v5/i2/82.htm
DOI http://dx.doi.org/10.5499/wjr.v5.i2.82
Full Article (PDF) WJR-5-82.pdf
Full Article (Word) WJR-5-82.doc
Manuscript File 13041-Review.docx
Answering Reviewers 13041-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form 13041-Conflict-of-interest statement.pdf
Copyright License Agreement 13041-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 13041-Language certificate.pdf
Peer-review Report 13041-Peer-review(s).pdf
Scientific Misconduct Check 13041-Scientific misconduct check.pdf
Scientific Editor Work List 13041-Scientific editor work list.pdf