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4/15/2015 11:01:00 AM | Browse: 1075 | Download: 1307
Publication Name World Journal of Gastroenterology
Manuscript ID 13130
Country/Territory Italy
Received
2014-08-07 08:37
Peer-Review Started
2014-08-08 09:11
To Make the First Decision
2014-08-27 19:12
Return for Revision
2014-08-28 10:07
Revised
2014-09-30 06:08
Second Decision
2014-11-10 16:35
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-11-19 09:26
Articles in Press
2014-11-19 09:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
2015-03-18 22:56
Typeset the Manuscript
2015-03-30 19:02
Publish the Manuscript Online
2015-04-15 11:01
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Case Report
Article Title Failure of interferon- pre-treated mesenchymal stem cell treatment in a patient with crohn’s disease
Manuscript Source Unsolicited Manuscript
All Author List Andrea Taddio, Alberto Tommasini, Erica Valencic, Ettore Biagi, Giuliana Decorti, Sara De Iudicibus, Eva Cuzzoni, Giuseppe Gaipa, Raffaela Badolato, Alberto Prandini, Andrea Biondi and Alessandro Ventura
Funding Agency and Grant Number
Corresponding Author Andrea Taddio, MD, Institute for Maternal and Child Health - IRCCS “Burlo Garofolo” - Trieste and University of Trieste, via dell’Istria 65/1, 34100 Trieste, Italy. andrea.taddio@burlo.trieste.it
Key Words Autoimmune disease; Crohn’s disease; Interferon- pretreatment; Mesenchymal stem cells; Immune regulation
Core Tip This is the first report of a lack of clinical response using interferon-? pre-treated mesenchymal stem cell infusion in a patient with intractable Crohn’s disease. Data on the clinical effects of mesenchymal stem cell treatment in autoimmune disorders are sparse and usually report a good clinical response; however, since very few reports have been published, we think negative results are also worthy of attention. The use of mesenchymal stem cells pre-treated with interferon-? is also of interest, and the lack of clinical benefit of bone marrow-derived interferon-? pre-treated mesenchymal stem cell infusion has also been described, despite the lymphocyte immune regulation effect.
Publish Date 2015-04-15 11:01
Citation Taddio A, Tommasini A, Valencic E, Biagi E, Decorti G, De Iudicibus S, Cuzzoni E, Gaipa G, Badolato R, Prandini A, Biondi A, Ventura A. Failure of interferon- pre-treated mesenchymal stem cell treatment in a patient with crohn’s disease. World J Gastroenterol 2015; 21(14): 4379-4384
URL http://www.wjgnet.com/1007-9327/full/v21/i14/4379.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i14.4379
Full Article (PDF) WJG-21-4379.pdf
Full Article (Word) WJG-21-4379.doc
Manuscript File 13130-Review.doc
Answering Reviewers 13130-Answering reviewers.pdf
Copyright License Agreement 13130-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 13130-Language certificate.pdf
Peer-review Report 13130-Peer review(s).pdf
Scientific Misconduct Check 13130-CrossCheck.jpg
Scientific Editor Work List 13130-Scientific editor work list.pdf