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Articles Published Processes
2/9/2015 5:58:00 PM | Browse: 1038 | Download: 1364
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Received |
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2014-08-11 15:27 |
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Peer-Review Started |
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2014-08-11 15:36 |
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To Make the First Decision |
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2014-09-15 16:11 |
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Return for Revision |
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2014-09-22 08:28 |
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Revised |
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2014-10-04 23:48 |
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Second Decision |
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2014-11-10 16:37 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2014-11-19 09:31 |
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Articles in Press |
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2014-11-19 09:46 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-01-26 10:18 |
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Publish the Manuscript Online |
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2015-02-09 17:58 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Loss of CDX2 expression is associated with poor prognosis in colorectal cancer patients
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jeong Mo Bae, Tae Hun Lee, Nam-Yun Cho, Tae-You Kim and Gyeong Hoon Kang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National RD Program for Cancer Control, Ministry of Health and Welfare, South Korea |
0720540 |
| Korea Healthcare Technology R and D Project, Ministry for Health, Welfare and Family Affairs, South Korea |
A091081 |
| Basic Science Research Program through the National Research Foundation of Korea |
2010-0007579 |
| Mid-career Researcher Program through an NRF grant funded by the Ministry of Education, Science and Technology |
2011-0015646 |
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| Corresponding Author |
Gyeong Hoon Kang, MD, PhD, Professor, Department of Pathology, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 110-799, South Korea. ghkang@snu.ac.kr |
| Key Words |
CDX2; CpG island methylator phenotype; Microsatellite instability; Colorectal cancer; Survival |
| Core Tip |
CDX2 is considered a tumor-suppressor gene and its expression is decreased in some colorectal cancers (CRCs). Immunohistochemical analysis of two different anti-CDX2 primary antibodies revealed that 5.9% of CRCs showed loss of CDX2 expression. Loss of CDX2 expression is associated with CpG island methylator phenotype, microsatellite instability, aggressive tumor behavior and poor clinical outcome. Patients with loss of CDX2 expression showed poor clinical outcome in univariate and multivariate survival analyses. Loss of CDX2 expression can be used as an independent prognostic marker in CRCs, especially stage Ⅳ CRCs. |
| Publish Date |
2015-02-09 17:58 |
| Citation |
Bae JM, Lee TH, Cho NY, Kim TY, Kang GH. Loss of CDX2 expression is associated with poor prognosis in colorectal cancer patients. World J Gastroenterol 2015; 21(5): 1457-1467 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i5/1457.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i5.1457 |
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