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12/13/2014 7:02:00 PM | Browse: 584 | Download: 684
Publication Name World Journal of Diabetes
Manuscript ID 13208
Country of Manuscript Source Italy
Received
2014-08-12 08:28
Peer-Review Started
2014-08-12 20:10
To Make the First Decision
2014-10-14 17:54
Return for Revision
2014-10-17 09:01
Revised
2014-10-17 22:17
Second Decision
2014-11-03 17:06
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-11-03 17:20
Articles in Press
2014-11-03 17:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-11-26 17:39
Publish the Manuscript Online
2014-12-13 19:01
ISSN 1948-9358 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Endocrinology and Metabolism
Manuscript type Minireviews
Article Title Type 2 diabetes mellitus and Alzheimer’s disease
Manuscript Source Invited Manuscript
All Author List Mario Barbagallo and Ligia J Dominguez
Funding Agency and Grant Number
Correspondence To Mario Barbagallo, MD, Professor, Geriatric Unit, Department DIBIMIS, University of Palermo, Via del vespro, 129, 90127 Palermo, Italy. mario.barbagallo@unipa.it
Keywords Dementia; Alzheimer; Type 2 diabetes; Aging; Cognitive decline; Mild cognitive impairment; Insulin; Hypoglycemia; Hyperglycemia
Core Tip Epidemiological and biological evidences support a link between type 2 diabetes (DM2) and Alzheimer’s disease (AD). Persons with diabetes have increased incidence of cognitive decline and AD. Increased cortical and subcortical atrophy is present after controlling for vascular disease and inadequate cerebral circulation. Recent studies confirmed the role of insulin as possible link between DM2 and AD. Altered insulin signaling may contribute to AD biochemical and histopathological lesions. Hyperglycemia and hypoglycemia also have deleterious effects on cognitive function. Future trials would clarify the mechanistic link, and if cognitive decline may be prevented by an adequate metabolic control, and avoiding hypoglycemia.
Publish Date 2014-12-13 19:01
Citation Barbagallo M, Dominguez LJ. Type 2 diabetes mellitus and Alzheimer’s disease. World J Diabetes 2014; 5(6): 889-893
Url http://www.wjgnet.com/1948-9358/full/v5/i6/889.htm
DOI http://dx.doi.org/10.4239/wjd.v5.i6.889
Full Article (PDF) WJD-5-889.pdf
Full Article (Word) WJD-5-889.doc
Manuscript File 13208-Review.doc
Answering Reviewers 13208-Answering reviewers.pdf
Copyright License Agreement 13208-Copyright assignment.pdf
Peer-review Report 13208-Peer review(s).pdf
Scientific Misconduct Check 13208-CrossCheck.jpg
Scientific Editor Work List 13208-Scientific editor work list.pdf