Publication Name	World Journal of Cardiology
Manuscript ID	13450
Country

Received	2014-08-23 08:21
Peer-Review Started	2014-08-23 16:54
First Decision by Editorial Office Director
Return for Revision	2014-10-08 13:47
Revised	2014-10-08 22:48
Publication Fee Transferred
Second Decision by Editor	2014-11-21 12:20
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-12-01 14:00
Articles in Press	2014-12-01 14:00
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-12-25 17:41
Publish the Manuscript Online	2014-12-29 09:19

ISSN	1949-8462 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Editorial
Article Title	Etiology of bicuspid aortic valve disease: Focus on hemodynamics
Manuscript Source	Invited Manuscript
All Author List	Samantha K Atkins and Philippe Sucosky
Funding Agency and Grant Number
Corresponding Author	Philippe Sucosky, PhD, FAHA, Department of Aerospace and Mechanical Engineering, University of Notre Dame, 143 Multidisciplinary Research Building, Notre Dame, IN 46556-5637, United States. philippe.sucosky@nd.edu
Key Words	Aortopathy; Valvulopathy; Hemodynamics; Bicuspid aortic valve; Shear stress
Core Tip	The bicuspid aortic valve (BAV) is associated with secondary aortopathy and valvulopathy. However, the root cause of those complications remains controversial. While the genetic etiology has been the most popular historically, advances in cardiovascular imaging, flow characterization and tissue culture methodologies have provided new evidence in support of a hemodynamic origin. The assessment of the respective role of genetic and hemodynamic cues in BAV pathogenesis is critical to the development of improved diagnosis tools and patient-specific modalities. This editorial discusses the different possible etiologies of BAV disease with a particular focus on the most recent evidence for the hemodynamic pathway.
Publish Date	2014-12-29 09:19
Citation	Atkins SK, Sucosky P. Etiology of bicuspid aortic valve disease: Focus on hemodynamics. World J Cardiol 2014; 6(12): 1227-1233
URL	http://www.wjgnet.com/1949-8462/full/v6/i12/1227.htm
DOI	http://dx.doi.org/10.4330/wjc.v6.i12.1227

Full Article (PDF)	WJC-6-1227.pdf
Full Article (Word)	WJC-6-1227.doc
Manuscript File	13450-Review.docx
Answering Reviewers	13450-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	13450-Conflict-of-interest statement.pdf
Copyright License Agreement	13450-Copyright assignment.pdf
Peer-review Report	13450-Peer review(s).pdf
Scientific Misconduct Check	13450-CrossCheck.jpg
Scientific Editor Work List	13450-Scientific editor work list.pdf