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12/13/2014 5:50:00 PM | Browse: 948 | Download: 1015
Publication Name World Journal of Hepatology
Manuscript ID 13539
Country/Territory Japan
Received
2014-08-27 08:56
Peer-Review Started
2014-08-27 14:18
To Make the First Decision
2014-09-16 10:54
Return for Revision
2014-09-19 16:34
Revised
2014-10-03 21:20
Second Decision
2014-10-27 16:57
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-10-27 17:16
Articles in Press
2014-10-27 17:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-12-08 17:56
Publish the Manuscript Online
2014-12-13 17:50
ISSN 1948-5182 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Food Science & Technology
Manuscript Type Topic Highlights
Article Title Functional foods effective for hepatitis C: Identification of oligomeric proanthocyanidin and its action mechanism
Manuscript Source Invited Manuscript
All Author List Yo-ichi Ishida, Masahiko Takeshita and Hiroaki Kataoka
Funding Agency and Grant Number
Funding Agency Grant Number
Japan Science and Technology Agency
Corresponding Author Hiroaki Kataoka, MD, PhD, Professor, Section of Oncopathology and Regenerative Biology, Department of Pathology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan. mejina@med.miyazaki-u.ac.jp
Key Words Hepatitis C virus; Blueberry leaves; Functional foods; Oligomeric proanthocyanidin; Heterogeneous nuclear ribonucleoproteins
Core Tip An infection by hepatitis C virus (HCV) causes chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. While the combination of pegylated α-interferon and ribavirin is used for the elimination of HCV, a new anti-HCV drug is required due to the poor efficacy and serious side-effects associated with this combination therapy. We searched for new anti-HCV agents from natural products and then identified oligomeric proanthocyanidin from blueberry leaves. Further investigations suggested that several heterogeneous nuclear ribonucleoproteins may be the candidate proteins involved in the proanthocyanidin-mediated inhibition of HCV subgenomic expression. Oligomeric proanthocyanidin isolated from blueberry leaves may have potential usefulness as an anti-HCV compound.
Publish Date 2014-12-13 17:50
Citation Ishida Y, Takeshita M, Kataoka H. Functional foods effective for hepatitis C: Identification of oligomeric proanthocyanidin and its action mechanism. World J Hepatol 2014; 6(12): 870-879
URL http://www.wjgnet.com/1948-5182/full/v6/i12/870.htm
DOI http://dx.doi.org/10.4254/wjh.v6.i12.870
Full Article (PDF) WJH-6-870.pdf
Full Article (Word) WJH-6-870.doc
Manuscript File 13539-Review.doc
Answering Reviewers 13539-Answering reviewers.pdf
Copyright License Agreement 13539-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate Editing_Certificate_20140826214409.pdf
Peer-review Report 13539-Peer review(s).pdf
Scientific Misconduct Check 13539-CrossCheck.jpg
Scientific Editor Work List 13539-Scientific editor work list.pdf