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1/10/2015 4:31:00 PM | Browse: 1170 | Download: 1121
Publication Name World Journal of Hepatology
Manuscript ID 13625
Country/Territory South Korea
Received
2014-08-28 17:33
Peer-Review Started
2014-08-28 19:28
To Make the First Decision
2014-09-28 12:26
Return for Revision
2014-09-30 15:49
Revised
2014-10-12 18:26
Second Decision
2014-10-29 17:54
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-10-29 18:50
Articles in Press
2014-10-29 18:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-11-05 18:05
Typeset the Manuscript
2014-12-26 14:37
Publish the Manuscript Online
2015-01-10 16:31
ISSN 1948-5182 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Minireviews
Article Title Clinical utility of complex mutations in the core promoter and proximal precore regions of the hepatitis B virus genome
Manuscript Source Invited Manuscript
All Author List Young Min Park
Funding Agency and Grant Number
Corresponding Author Young Min Park, MD, PhD, Hepatology Center, Department of Internal Medicine, Bundang Jesaeng General Hospital, 255-2, Seohyun-dong, Bundang-gu, Seongnam-si, Kyungki-do 463-774, South Korea. ymp1@outlook.com
Key Words Hepatitis B virus; Point mutation; Hepatitis B virus X protein; Hepatocellular carcinoma; Cancer screening
Core Tip Multiple mutations in the core promoter and proximal precore regions of the hepatitis B virus (HBV) genome are associated with hepatocellular carcinoma (HCC), but mutations predictive of outcome in chronic HBV carriers have not been distinguished. In the Korean HBV genotype C2, the number of mutations at eight key nucleotides located in these regions (G1613A, C1653T, T1753V, A1762T, G1764A, A1846T, G1896A, and G1899A) is positively correlated with HCC. In addition, some selected mutation combinations among individuals with ≥ 4 mutations are predominant in the HCC group.
Publish Date 2015-01-10 16:31
Citation Park YM. Clinical utility of complex mutations in the core promoter and proximal precore regions of the hepatitis B virus genome. World J Hepatol 2015; 7(1): 113-120
URL http://www.wjgnet.com/1948-5182/full/v7/i1/113.htm
DOI http://dx.doi.org/10.4254/wjh.v7.i1.113
Full Article (PDF) WJH-7-1.pdf
Full Article (Word) WJH-7-1.doc
Manuscript File 13625-Review.docx
Answering Reviewers 13625-Answering reviewers.pdf
Copyright License Agreement 13625-Copyright assignment.pdf
Peer-review Report 13625-Peer review(s).pdf
Scientific Misconduct Check 13625-CrossCheck.jpg
Scientific Editor Work List 13625-Scientific editor work list.pdf