Publication Name	World Journal of Nephrology
Manuscript ID	13668
Country	Italy

Received	2014-08-29 10:35
Peer-Review Started	2014-08-30 20:00
To Make the First Decision	2014-12-02 16:39
Return for Revision	2014-12-02 16:55
Revised	2014-12-04 22:29
Second Decision	2015-01-08 16:45
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-01-19 13:47
Articles in Press	2015-01-19 13:47
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-04-09 09:03
Publish the Manuscript Online	2015-05-08 14:17

ISSN	2220-6124 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Urology & Nephrology
Manuscript Type	Review
Article Title	Complement involvement in kidney diseases: From physiopatology to therapeutical targeting
Manuscript Source	Invited Manuscript
All Author List	Maurizio Salvadori, Giuseppina Rosso and Elisabetta Bertoni
Funding Agency and Grant Number
Corresponding Author	Maurizio Salvadori, MD, Department of renal transplantation, Careggi University Hospital, viale Pieraccini 18, 50139 Florence, Italy. maurizio.salvadori1@gmail.com
Key Words	Complement cascade; Complement and glomerulopathies; Complement and renal transplantation; Targeting complement; Eculizumab
Core Tip	Our therapeutical armamentarium is to date limited in many kidney diseases and in several aspects of renal transplantation. The findings that complement cascade are involved in many kidney diseases and in renal transplantation offer the availability of new therapeutical targets basing on the pathogenesis. The anti C5 monoclonal antibody, eculizumab, is now used to treat the atypical hemolytic uremic syndrome (aHUS), but 24 trials are ongoing in different renal diseases and in renal transplantation. Other targets as C1, C3, C5a, and C5aR are innovative treatments for diseases as aHUS, membranoproliferative glomerulonephritis, ischemia-reperfusion injury, and objects of ongoing trials.
Publish Date	2015-05-08 14:17
Citation	Salvadori M, Rosso G, Bertoni E. Complement involvement in kidney diseases: From physiopathology to therapeutical targeting. World J Nephrol 2015; 4(2): 169-184
URL	http://www.wjgnet.com/2220-6124/full/v4/i2/169.htm
DOI	http://dx.doi.org/10.5527/wjn.v4.i2.169

Full Article (PDF)	WJN-4-169.pdf
Full Article (Word)	WJN-4-169.doc
Manuscript File	13668-Review.docx
Answering Reviewers	13668-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	13668-Conflict-of-interest statement.pdf
Copyright License Agreement	13668-Copyright assignment.pdf
Peer-review Report	13668-Peer review(s).pdf
Scientific Misconduct Check	13668-CrossCheck.jpg
Scientific Editor Work List	13668-Scientific editor work list.pdf