Publication Name	World Journal of Hepatology
Manuscript ID	13715
Country	United States

Received	2014-08-29 08:19
Peer-Review Started	2014-08-29 17:19
To Make the First Decision	2014-12-17 11:36
Return for Revision	2014-12-18 17:16
Revised	2015-03-04 00:00
Second Decision	2015-04-15 17:53
Accepted by Journal Editor-in-Chief	2015-04-15 18:31
Accepted by Company Editor-in-Chief	2015-04-29 15:31
Articles in Press	2015-04-29 15:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-05-30 12:17
Publish the Manuscript Online	2015-06-16 14:22

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Review
Article Title	Multidisciplinary perspective of hepatocellular carcinoma: A Pacific Northwest experience
Manuscript Source	Invited Manuscript
All Author List	Matthew M Yeh, Raymond S Yeung, Smith Apisarnthanarax, Renuka Bhattacharya, Carlos Cuevas, William P Harris, Tony Lim Kiat Hon, Siddharth A Padia, James O Park, Kevin M Riggle and Sayed S Daoud
Funding Agency and Grant Number
Corresponding Author	Sayed S Daoud, PhD, Department of Pharmaceutical Sciences, Washington State University Health Sciences, 412 E Spokane Falls Blvd, Spokane, WA 99210, United States. daoud@wsu.edu
Key Words	Genetic alterations; Epigenetic alterations; Diagnostic pathology; Diagnostic imaging; Surgical modality; Liver transplantation; Locoregional therapy; Sorafenib; Hepatocellular carcinoma; Liver resection
Core Tip	Hepatocellular carcinoma (HCC) is one of the few tumors in which the incidence is on the rise worldwide, especially in the United States. The overall increase in the incidence warrants efforts to prevent and to more efficiently treat this disease. This necessitates the need for a multidisciplinary approach for the management of HCC, because there are many etiological factors involved in the pathogenesis and malignant transformation of the disease. For example, there is a need to improve surveillance and early diagnosis through diagnostic imaging modalities to facilitate identification of potential molecular targets for novel therapeutic strategies. In turn, this will facilitate the identification of patients at risk. This review summarizes current knowledge on the clinical management of the disease as well as etiologic mechanisms of malignant transformation for better diagnosis, prognosis, and treatment of HCC.
Publish Date	2015-06-16 14:22
Citation	Yeh MM, Yeung RS, Apisarnthanarax S, Bhattacharya R, Cuevas C, Harris WP, Hon TLK, Padia SA, Park JO, Riggle KM, Daoud SS. Multidisciplinary perspective of hepatocellular carcinoma: A Pacific Northwest experience. World J Hepatol 2015; 7(11): 1460-1483
URL	http://www.wjgnet.com/1948-5182/full/v7/i11/1460.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i11.1460

Full Article (PDF)	WJH-7-1460.pdf
Full Article (Word)	WJH-7-1460.doc
Manuscript File	13715-Review.doc
Answering Reviewers	13715-Answering reviewers.pdf
Audio Core Tip	13715-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	13715-Conflict-of-interest statement.pdf
Copyright License Agreement	13715-Copyright assignment.pdf
Peer-review Report	13715-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	13715-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	13715-Scientific misconduct check.pdf
Scientific Editor Work List	13715-Scientific editor work list.pdf