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4/27/2015 4:29:00 PM | Browse: 607 | Download: 562
Publication Name World Journal of Gastroenterology
Manuscript ID 13827
Country/Territory United States
2014-09-03 08:16
Peer-Review Started
2014-09-04 14:26
To Make the First Decision
2014-10-14 16:51
Return for Revision
2014-10-17 21:47
2014-11-03 22:17
Second Decision
2014-11-24 11:55
Accepted by Journal Editor-in-Chief
2014-11-25 19:02
Accepted by Company Editor-in-Chief
2014-12-08 16:22
Articles in Press
2014-12-08 17:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-04-12 18:23
Publish the Manuscript Online
2015-04-27 16:22
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Murine study of portal hypertension associated endothelin-1 hypo-response
Manuscript Source Unsolicited Manuscript
All Author List Nicholas Theodorakis, Mary Maluccio and Nicholas Skill
Funding Agency and Grant Number
Funding Agency Grant Number
Indiana University department of surgery and Lilly INGEN research fund
Corresponding Author Nicholas Skill, PhD, Assistant Research Professor, Department of Surgery, Division of Transplant Surgery, Indiana School of Medicine, Indiana University, Walthur Cancer Research Building, Rm C519. 980 W. Walnut Street, Indianapolis, IN 46202, United States. nskill@iupui.edu
Key Words Liver disease; Portal hypertension; Hyper-dynamic circulation; Endothelin-1; Nitric oxide synthase isoforms
Core Tip Portal hypertension (PHT) is a complication associated with vascular derangements in response to liver disease and fibrosis. Perturbations of nitric oxide (NO) and endothelin-1 are believed to be interrelated and play a key role in PHT vasculopathy. This study investigates the importance of NO biosynthesis in endothelin-1 vasoconstriction hypo-response seen in patients with PHT. PHT was induced in wild type, eNOS-/- and iNOS-/- mice by partial portal vein ligation (PVL) and endothelin-1 contractile response was determined. Endothelin-1 (ET-1) induced contraction was significantly reduced following PVL in all mouse groups. Aberrant ET-1 function associated with PHT is NO independent.
Publish Date 2015-04-27 16:22
Citation Theodorakis N, Maluccio M, Skill N. Murine study of portal hypertension associated endothelin-1 hypo-response. World J Gastroenterol 2015; 21(16): 4817-4828
URL http://www.wjgnet.com/1007-9327/full/v21/i16/4817.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i16.4817
Full Article (PDF) WJG-21-4817.pdf
Full Article (Word) WJG-21-4817.doc
Manuscript File 13827-Review.docx
Answering Reviewers 13827-Answering reviewers.pdf
Copyright License Agreement 13827-Copyright assignment.pdf
Peer-review Report 13827-Peer review(s).pdf
Scientific Misconduct Check 13827-CrossCheck.jpg
Scientific Editor Work List 13827-Scientific editor work list.pdf