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4/7/2015 6:08:00 PM | Browse: 480 | Download: 914
Publication Name World Journal of Gastroenterology
Manuscript ID 13834
Country/Territory Taiwan
Received
2014-09-03 17:45
Peer-Review Started
2014-09-04 16:19
To Make the First Decision
2014-09-27 16:34
Return for Revision
2014-10-10 08:35
Revised
2014-11-07 23:36
Second Decision
2014-12-08 14:44
Accepted by Journal Editor-in-Chief
2014-12-10 09:52
Accepted by Company Editor-in-Chief
2014-12-16 10:16
Articles in Press
2014-12-16 10:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-12-30 09:06
Typeset the Manuscript
2015-03-24 15:58
Publish the Manuscript Online
2015-04-07 17:13
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Retrospective Study
Article Title Methylation of IRAK3 is a novel prognostic marker in hepatocellular carcinoma
Manuscript Source Invited Manuscript
All Author List Chih-Chi Kuo, Yu-Lueng Shih, Her-Young Su, Ming-De Yan, Chung-Bao Hsieh, Chin-Yu Liu, Wei-Ting Huang, Mu-Hsien Yu and Ya-Wen Lin
Funding Agency and Grant Number
Funding Agency Grant Number
National Science Council, Taiwan NSC 102-2320-B-016-016-MY3
Liver Disease Prevention and Treatment Research Foundation, Taiwan
Corresponding author Ya-Wen Lin, PhD, Department and Graduate Institute of Microbiology and Immunology, Graduate Institute of Medical Sciences, National Defense Medical Center, No. 161, Section 6, Min-Chuan East Road, Taipei 114, Taiwan. ndmc.yawen@msa.hinet.net
Keywords IRAK3; GLOXD1; Hepatocellular carcinoma; DNA methylation biomarker; Quantitative methylation-specific polymerase chain reaction; Pyrosequencing
Core Tip The methylation biomarker is relatively stable in tissue samples and body fluids, suggesting that it is a good tool for the detection, diagnosis, prognosis, and even therapy of hepatocellular carcinoma (HCC). Our study not only demonstrated frequent methylation of interleukin-1 receptor-associated kinase 3 (IRAK3) and GLOXD1 in HCC but also found that IRAK3 methylation was positively associated with poor 3-year disease-free survival of patients. This indicates that IRAK3 methylation could be used as a potential biomarker for prediction of prognosis in HCC.
Publish Date 2015-04-07 17:13
Citation Kuo CC, Shih YL, Su HY, Yan MD, Hsieh CB, Liu CY, Huang WT, Yu MH, Lin YW. Methylation of IRAK3 is a novel prognostic marker in hepatocellular carcinoma. World J Gastroenterol 2015; 21(13): 3960-3969
Url http://www.wjgnet.com/1007-9327/full/v21/i13/3960.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i13.3960
Full Article (PDF) WJG-21-3960.pdf
Full Article (Word) WJG-21-3960.doc
Manuscript File 13834-Review.doc
Answering Reviewers 13834-Answering reviewers.pdf
Biostatistics Review Certificate 13834-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 13834-Conflict-of-interest statement.pdf
Copyright License Agreement 13834-Copyright assignment.pdf
Data Sharing Statement 13834-Data sharing statement.pdf
Institutional Review Board Approval Form or Document 13834-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 13834-Language certificate.pdf
Peer-review Report 13834-Peer review(s).pdf
Scientific Misconduct Check 13834-CrossCheck.jpg
Scientific Editor Work List 13834-Scientific editor work list.pdf