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4/30/2015 2:11:00 PM | Browse: 801 | Download: 680
Publication Name World Journal of Gastroenterology
Manuscript ID 13924
Country/Territory Australia
Received
2014-09-09 08:24
Peer-Review Started
2014-09-09 14:40
To Make the First Decision
2014-10-14 17:00
Return for Revision
2014-10-15 17:19
Revised
2014-12-22 23:58
Second Decision
2015-01-08 13:10
Accepted by Journal Editor-in-Chief
2015-01-10 14:19
Accepted by Company Editor-in-Chief
2015-01-16 17:31
Articles in Press
2015-01-16 18:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-04-07 18:37
Publish the Manuscript Online
2015-04-20 15:10
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Virology
Manuscript Type Clinical Trials Study
Article Title Covalently closed-circular hepatitis B virus DNA reduction with entecavir or lamivudine
Manuscript Source Invited Manuscript
All Author List Scott Bowden, Stephen Locarnini, Ting-Tsung Chang, You-Chen Chao, Kwang-Hyub Han, Robert G Gish, Robert A de Man, Miao Yu, Cyril Llamoso and Hong Tang
Funding Agency and Grant Number
Funding Agency Grant Number
Bristol-Myers Squibb
Corresponding Author Scott Bowden, PhD, Victorian Infectious Diseases Reference Laboratory, 792 Elizabeth Street, Melbourne, Victoria 3000, Australia. scott.bowden@mh.org.au
Key Words Hepatitis B virus; Nucleos(t)ide analog therapy; Intrahepatic hepatitis B virus DNA; Antiviral suppression; Virologic cure
Core Tip In chronic hepatitis B, persistence of hepatitis B virus (HBV) infection is due to an intrahepatic pool of stable, HBV covalently closed-circular DNA (cccDNA), whose elimination is a limiting factor in anti-HBV treatment. This study shows that 48 weeks of treatment with entecavir resulted in a greater reduction of hepatic HBV cccDNA and total hepatic HBV DNA than lamivudine. However, cccDNA was still detectable in most biopsies, suggesting that despite potent viral suppression with entecavir, prolonged treatment may be needed to eradicate cccDNA.
Publish Date 2015-04-20 15:10
Citation Bowden S, Locarnini S, Chang TT, Chao YC, Han KH, Gish RG, de Man RA, Yu M, Llamoso C, Tang H. Covalently closed-circular hepatitis B virus DNA reduction with entecavir or lamivudine. World J Gastroenterol 2015; 21(15): 4644-4651
URL http://www.wjgnet.com/1007-9327/full/v21/i15/4644.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i15.4644
Full Article (PDF) WJG-21-4644.pdf
Full Article (Word) WJG-21-4644.doc
Manuscript File 13924-Review.docx
Answering Reviewers 13924-Answering reviewers.pdf
Copyright License Agreement 13924-Copyright assignment.pdf
Peer-review Report 13924-Peer-review(s).pdf
Scientific Misconduct Check 13924-CorssCheck.jpg
Scientific Editor Work List 13924-Scientific editor work list.pdf