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1/31/2015 2:38:00 PM | Browse: 1083 | Download: 1631
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Received |
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2014-09-09 08:09 |
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Peer-Review Started |
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2014-09-09 15:04 |
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To Make the First Decision |
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2014-10-14 17:32 |
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Return for Revision |
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2014-10-20 08:11 |
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Revised |
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2014-11-03 21:06 |
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Second Decision |
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2014-12-10 11:31 |
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Accepted by Journal Editor-in-Chief |
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2014-12-11 18:48 |
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Accepted by Company Editor-in-Chief |
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2014-12-17 16:21 |
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Articles in Press |
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2014-12-17 16:21 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-01-15 16:58 |
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Publish the Manuscript Online |
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2015-01-31 14:38 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Review |
| Article Title |
Pathological consequences of C-peptide deficiency in insulin-dependent diabetes mellitus
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ahmad Ghorbani and Reza Shafiee-Nick |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Mashhad University of Medical Sciences |
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| Corresponding Author |
Reza Shafiee-Nick, Pharm D, PhD, Department of Pharmacology, School of Medicine, Mashhad University of Medical Sciences, Pardis Campus, Azadi Square, 91375-3316 Mashhad, Iran. shafieer@mums.ac.ir |
| Key Words |
C-peptide; Diabetes; Insulin; Nephropathy; Neuropathy |
| Core Tip |
In type-1 diabetes, in addition to decrease of endogenous insulin, the plasma level of connecting peptide (C-peptide) is also reduced due to beta cell destruction. Therefore, it may be possible that C-peptide deficiency be involved in the development of diabetic complications such as retinopathy, nephropathy, neuropathy and cardiovascular diseases. In this paper, beneficial effects of C-peptide replacement on pathological features associated with type-1 diabetes are described. Also, experimental and clinical findings that support the hypoglycemic, antilipolytic and vasodilator effects of C-peptide are discussed. |
| Publish Date |
2015-01-31 14:38 |
| Citation |
Ghorbani A, Shafiee-Nick R. Pathological consequences of C-peptide deficiency in insulin-dependent diabetes mellitus. World J Diabetes 2015; 6(1): 145-150 |
| URL |
http://www.wjgnet.com/1948-9358/full/v6/i1/145.htm |
| DOI |
http://dx.doi.org/10.4239/wjd.v6.i1.145 |
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