Publication Name	World Journal of Hepatology
Manuscript ID	14091
Country	India

Received	2014-09-18 09:47
Peer-Review Started	2014-09-20 16:37
To Make the First Decision	2014-12-17 11:36
Return for Revision	2014-12-21 18:02
Revised	2015-01-30 23:53
Second Decision	2015-03-16 17:46
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-04-02 16:16
Articles in Press	2015-04-02 16:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-05-20 10:00
Publish the Manuscript Online	2015-06-16 14:22

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Biochemistry & Molecular Biology
Manuscript Type	Minireviews
Article Title	Th1/Th2 cytokines and their genotypes as predictors of hepatitis B virus related hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Roli Saxena and Jyotdeep Kaur
Funding Agency and Grant Number
Corresponding Author	Dr. Jyotdeep Kaur, PhD, Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh 160012, India. jyotdeep2001@yahoo.co.in
Key Words	Hepatitis B virus; Hepatocellular carcinoma; Inflammation; Th1/Th1 cytokine; Polymorphism
Core Tip	Hepatocellular carcinoma is the prime mani-festation of primary liver cancer. Besides, hepatitis B virus (HBV) infection accounts for nearly 50% of hepatocellular carcinoma cases worldwide. The injuries afflicted by HBV infection are predominantly immune-mediated. Th1/Th2 cytokines play a significant role in modulating almost all phases of the host immune response. Moreover, cytokine production and response is genetically controlled. Hence, the population-based variability in patterns of cytokine polymorphisms, might alter the ability of an individual to mount an appropriate immune response, thus causing a differential effect on the progression of the HBV disease pathogenesis.
Publish Date	2015-06-16 14:22
Citation	Saxena R, Kaur J. Th1/Th2 cytokines and their genotypes as predictors of hepatitis B virus related hepatocellular carcinoma. World J Hepatol 2015; 7(11): 1572-1580
URL	http://www.wjgnet.com/1948-5182/full/v7/i11/1572.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i11.1572

Full Article (PDF)	WJH-7-1572.pdf
Full Article (Word)	WJH-7-1572.doc
Manuscript File	14091-Review.docx
Answering Reviewers	14091-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	14091-Conflict-of-interest statement.pdf
Copyright License Agreement	14091-Copyright assignment.pdf
Peer-review Report	14091-Peer-review(s).pdf
Scientific Misconduct Check	14091-Scientific misconduct check.pdf
Scientific Editor Work List	14091-Scientific editor work list.pdf