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4/27/2015 4:29:00 PM | Browse: 875 | Download: 1107
Publication Name World Journal of Gastroenterology
Manuscript ID 14176
Country/Territory South Korea
Received
2014-09-23 14:41
Peer-Review Started
2014-09-25 08:45
To Make the First Decision
2014-10-14 16:44
Return for Revision
2014-10-20 13:28
Revised
2014-10-30 12:07
Second Decision
2015-01-12 14:00
Accepted by Journal Editor-in-Chief
2015-01-14 09:26
Accepted by Company Editor-in-Chief
2015-01-16 18:10
Articles in Press
2015-01-16 18:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-04-10 18:10
Publish the Manuscript Online
2015-04-27 16:22
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Infectious Diseases
Manuscript Type Evidence-Based Medicine
Article Title Hepatitis B virus preS1 deletion is related to viral replication increase and disease progression
Manuscript Source Unsolicited Manuscript
All Author List Seoung-Ae Lee, Ki-Jeong Kim, Hong Kim, Won-Hyuk Choi, Yu-Sub Won and Bum-Joon Kim
Funding Agency and Grant Number
Funding Agency Grant Number
National Research Foundation of Korea
Korean government (Ministry of Education, Science, and Technology) 2013-005810
Foundation of Seoul National University Hospital 0320140140
Corresponding Author Bum-Joon Kim, Professor, Department of Biomedical Sciences, Microbiology and Immunology, and Liver Research Institute, Seoul National University College of Medicine, Seoul 110-799, South Korea. kbumjoon@snu.ac.kr
Key Words Hepatitis B virus; PreS1 start codon deletion; Hepatitis B virus e antigen; Hepatocellular carcinoma; Genotype C
Core Tip Our data indicate that the hepatitis B virus (HBV) genotype C preS1 deletion might significantly contribute to disease progression in chronic HBV subjects through an extended duration of Hepatitis B virus e antigen seropositive status and increased HBV replication. This study provides novel insight into the greater infectivity and virulence of genotype C compared with other genotypes. In addition, the fluorescence resonance energy transfer-based real-time polymerase chain reaction used to detect the preS1 deletion shows promise for the earlier prediction of the risk of liver disease progression in chronic HBV subjects.
Publish Date 2015-04-27 16:22
Citation Lee SA, Kim KJ, Kim H, Choi WH, Won YS, Kim BJ. Hepatitis B virus preS1 deletion is related to viral replication increase and disease progression. World J Gastroenterol 2015; 21(16): 5039-5048
URL http://www.wjgnet.com/1007-9327/full/v21/i16/5039.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i16.5039
Full Article (PDF) WJG-21-5039.pdf
Full Article (Word) WJG-21-5039.doc
Manuscript File 14176-Review.docx
Answering Reviewers 14176-Answering reviewers.pdf
Copyright License Agreement 14176-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 14176-Language certificate.pdf
Peer-review Report 14176-Peer-review(s).pdf
Scientific Misconduct Check 14176-CrossCheck.jpg
Scientific Editor Work List 14176-Scientific editor work list.pdf