Publication Name	World Journal of Critical Care Medicine
Manuscript ID	14244
Country	Argentina

Received	2014-09-26 08:55
Peer-Review Started	2014-09-28 22:19
To Make the First Decision	2014-12-17 11:27
Return for Revision	2014-12-19 10:51
Revised	2014-12-29 09:47
Second Decision	2015-01-08 16:58
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-01-19 13:37
Articles in Press	2015-01-19 13:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-02-05 17:49
Publish the Manuscript Online	2015-02-11 18:50

ISSN	2220-3141(online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Critical Care Medicine
Manuscript Type	Minireviews
Article Title	Has Stewart approach improved our ability to diagnose acid-base disorders in critically ill patients?
Manuscript Source	Invited Manuscript
All Author List	Fabio D Masevicius and Arnaldo Dubin
Funding Agency and Grant Number
Corresponding Author	Arnaldo Dubin, MD, PhD, Servicio de Terapia Intensiva, Sanatorio Otamendi y Miroli, Azcuénaga 870, C1115AAB Ciudad Autónoma de Buenos Aires, Argentina. arnaldodubin@gmail.com
Key Words	Acid-base metabolism; Stewart approach; Base excess; Bicarbonate; Anion gap; Strong ion difference; Strong ion gap
Core Tip	In this article, we comprehensively reviewed the evidence that has been used to argue for the superiority of the Stewart approach over the traditional method for the analysis of acid-base metabolism in critically ill patients. The basic principles of the Stewart approach have severe weaknesses. In addition, the contribution of this method to the understanding of mechanisms is minor; furthermore, from a clinical standpoint, the Stewart approach has no advantage for diagnostic or prognostic purposes compared to the analysis based on bicarbonate, base excess, and albumin-corrected anion gap.
Publish Date	2015-02-11 18:50
Citation	Masevicius FD, Dubin A. Has Stewart approach improved our ability to diagnose acid-base disorders in critically ill patients? World J Crit Care Med 2015; 4(1): 62-70
URL	http://www.wjgnet.com/2220-3141/full/v4/i1/62.htm
DOI	http://dx.doi.org/10.5492/wjccm.v4.i1.62

Full Article (PDF)	WJCCM-4-62.pdf
Full Article (Word)	WJCCM-4-62.doc
Manuscript File	14244-Review.doc
Answering Reviewers	14244-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	14244-Conflict-of-interest statement.pdf
Copyright License Agreement	14244-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	14244-Language certificate.pdf
Peer-review Report	14244-Peer review(s).pdf
Scientific Misconduct Check	14244-CrossCheck.jpg
Scientific Editor Work List	14244-Scientific editor work list.pdf